1/x True story that highlights the loss of autonomy and agency by physicians - the force that results in more burnout than any other:

A physician colleague of mine in a different practice that was recently acquired by a major financial firm was on back-up call….. He was in a surgical discipline and got called to help in a challenging case that kept him in the or from midnight until 5am. The medical emergency resulted in major trauma to young woman but saved her life

BTK inhibitors have transformed the lives of many patients with Chronic Lymphocytic Leukemia and other lymphomas. These drugs "exploded" onto the scene in 2013-2014 and have fundamentally changed the way we treat the disease. What many people don't know is how it all happened.. In 2004 I became convinced that turning off B-cell receptor signaling would cause cancerous b-cells to stop growing. This theory came into focus based upon an understanding of epstein barr virus protein LMP2A, EBV relationship to Hodgkin lymphoma, and other breadcrumbs

Re: #COVID19 / #Hydroxychloroquine - single arm phase 2 data is the scientific equivalent of a hypothesis - don’t confuse larger number of uncontrolled patients as evidence - it is only the volume with which you are yelling. Proof requires randomized studies @VPrasadMDMPH Sometimes uncontrolled ph2 studies show “preliminary findings” that in the judgement of experts render the “hypothesis” compelling or encouraging, but you still cannot argue that it is proof something works. And yes - the therapy “can still hurt” @realDonaldTrump