Melodem (Methods in longitudinal dementia research) is an international initiative aiming at strengthening research on Alzheimer's and dementia.
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Mar 18, 2021 • 24 tweets • 5 min read
Looking forward to this morning's MELODEM presentation from Dr. Lon Schneider: "“Alzheimer clinical drug development: Methodological features and FDA’s regulatory guidance on aducanumab”"
Dr. Schneider starts with disclosures (many, won't detail here, but including many pharma). Notes that the "drama of aducanumab" involves many themes at the heart of MELODEM
Apr 16, 2020 • 4 tweets • 1 min read
Accounting for mode differences in the measurement properties indicates people who took the phone assessment look worse. Questions re domain differences and also difference in extremes, not just means. Alden looked at raw test scores by mode and didn't see much major.
@ManlyEpic asks what are the predictors of big mode effects eg age education. Ron Spiro adds note that some domains just cannot be assessed via phone.
Jan 28, 2020 • 10 tweets • 2 min read
Applications are open for the 2020 MELODEM Annual Meeting! bit.ly/38Qo7c7 1/9
MELODEM is an international initiative that aims to strengthen, harmonize, and disseminate analytic and design approaches for research on Alzheimer's disease and related dementias (ADRD) 2/9
Nov 14, 2019 • 13 tweets • 3 min read
MELODEM working group work in progress: Dr. Megha Mehrotra @Megtron9 re her work on transportability "If I had done this study in a different population, what would I have found?" @yudapearl@eliasbareinboim
Source popl'n (where you did the study-the population you are transporting from) is S=1. Whereas target population, the population you hope to generalize/transport to is S=0. Distinguishing transporting and generalizing-see @EpidByDesign's
Jan 21, 2019 • 14 tweets • 7 min read
announcing this week's topic - #validity of dementia diagnosis, and how does it relate to use of administrative databases for #dementia research!
1/n bit of basic #epidemiology first: Gold standard measures are used to assess the validity of alternative measurement #epitwitter
Nov 11, 2018 • 4 tweets • 1 min read
MELODEM aims to enhance the rigor of research on Alzheimer's Disease and other causes of dementia via identifying methods problems, sharing best practices, and prompting methodological innovation. Our 2015 guidelines paper outlined common challenges in dementia research.
MELODEM guideline princip 1: Clarify the question. Is it causal or predictive? ID the population. Define the estimand you want. Explain assumptions (causal & statistical) you need to invoke to link your statistical result to your substantive question. alzheimersanddementia.com/article/S1552-…
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