Glad to share this Perspective written with @VirusesImmunity, where we review what is understood about how COVID can affect the brain, discuss the possible neurobiological underpinnings & propose the main mechanisms that may contribute to COVID brain fog🧵cell.com/neuron/fulltex… COVID may affect the central nervous system in (at least) six main ways. These mechanisms of nervous system injury are not mutually exclusive, and a combination of mechanisms may occur in some individuals, with varying frequency and timing. 2/

The final version of our study seeking to understand how even mild respiratory COVID can affect the brain is now published. Sharing an updated thread… 1/

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation cell.com/cell/fulltext/… COVID survivors frequently suffer from lasting cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 2/

#LongCOVID frequently includes cognitive symptoms. Noting the clinical similarities between “chemo-fog” and “COVID-fog”, we asked whether there are also neurobiological similarities, in collaboration with Akiko Iwasaki’s @VirusesImmunity lab @YaleMed. 🧵 biorxiv.org/content/10.110… How might even mild respiratory #COVID-19 infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity.