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Giovanni Pascarella Profile picture
Giovanni Pascarella
@muju79
Research Scientist @ RIKEN IMS
Jul 25, 2022 • 20 tweets • 8 min read
Beyond ecstatic to share that our paper is finally out @CellCellPress!
It's been a while since I lastly highlighted the main findings, so here's a refresher for new and old readers with some new data added during the peer-review process (-18)
doi.org/10.1016/j.cell… The background: roughly one base out of 3 in our genomes belongs to either an Alu or L1 repeat element. These are retrotransposons involved in a lot of cool things, here's an excellent primer if you want to know more about transposable elements (-17)
doi.org/10.1186/s13059…
Jul 3, 2020 • 11 tweets • 6 min read
Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:

Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110… 1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.