As 2022 draws to a close, we’ve been reflecting on some of the highlights (in no particular order) — you can read the full article here: bit.ly/3IfaKYc, or digest the thread below. Wishing you a happy new year and all the best for 2023! 1/23 The #cancer research community has made huge strides leveraging the unique attributes of #nanopore sequencing to characterise cancer at unprecedented resolution, unlocking previously hidden variation and accelerating research to support human health. nanoporetech.com/cancer-research 2/23

Time for the latest @nanopore technology updates. Up next in the auditorium: an Update from the Oxford Nanopore team. #nanoporeconf Please note, we invite you to read the disclaimer in the slides

Please take your seats for @gordon_sanghera's opening plenary of London Calling 2022. #nanoporeconf GS: Lord Kelvin believed in meaningful measurement to see the whole picture. With nanopore sequencing you gain more comprehensive insights than ever before. #nanoporeconf

Opening the Nanopore Community Meeting Tech Update is James Clarke, valiantly speaking through a bad, bad cold. We'll be live tweeting in this thread, with Stu Reid and Rosemary Dokos up next #nanoporeconf JC: @nanopore accuracy has come a long way. Right now, in just 3-4 seconds, I can pass 1,000 bases of a **single molecule** of DNA through a hole, and know its sequence with over 99% accuracy. That’s better than Q20, by looking at a single molecule - once #nanoporeconf

Up in a few minutes, Clive G Brown @the_taybor with a plenary talk on @nanopore sequencing. We'll live tweet in this thread 1/n #nanoporeconf @The_Taybor CB: our goal is to enable the analysis of anything, by anyone, anywhere #nanoporeconf

For those using @ArticNetwork Midnight for #SARSCoV2 sequencing: analysis of the available data (55 genomes) showed that 100% were correctly identified as Omicron. We’ve observed 1 amplicon dropout out of 29. This is outside of the S gene & does not impact correct lineage ID 1/4 Whilst the amplicon dropout does not affect identification of the Omicron variant, the Midnight kit will be revised to include an additional primer to improve amplification efficiency of Omicron Amplicon 28. We expect this to be available in 2-4 weeks 2/4

Coming up in a few minutes, Clive Brown @the_taybor, with an update entitled “Nobody Expects the Strandish Exposition”. Follow the talk live in this thread #nanoporeconf CB: Our goal is to enable the analysis of anything by anyone, anywhere. Here are some examples of global use: nanoporetech.com/portable-seque…

Opening the tech update at the Nanopore Community Meeting, from Oxford @Nanopore, James Clark, VP platform technology #nanoporeconf JC: a reminder that our goal is to enable the analysis of anything, by anyone, anywhere #nanoporeconf

And now at #nanoporeconf, an update from the team @RosemaryDokos, James Clarke and Stu Reid. A thread First up, James Clarke with an introduction to @nanopore sequencing. More than 1,000 publications use nanopore sequencing nanoporetech.com/resource-centre, and we estimate that ~1.7 petabases of nanopore sequence has been generated to date #nanoporeconf

Dan Turner @DanTurnez: an overview of LamPORE, the new nanopore based assay for the detection of SARS-CoV-2 at #nanoporeconf. A thread: DT: Why is the LamPORE, sequencing-based assay useful for SARS-CoV-2 detection? We think about bottlenecks: the ability to analyse very small or very large numbers of samples with a small footprint, rapid results, and efficient, precise analysis of known pathogens #nanoporeconf