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TLR7 loss-of-functions mutations can lead to an immunodeficiency with a strong predisposition to develop a severe form of COVID-19 in young male patients. jamanetwork.com/journals/jama/…
TLR7 loss-of-functions mutations can lead to an immunodeficiency with a strong predisposition to develop a severe form of COVID-19 in young male patients. jamanetwork.com/journals/jama/…
2/7 As such, this is the first description of a monogenic risk factor related to COVID-19 and a first risk factor next to the known general risk factors (age, male sex, cardiovascular disease, chronic disease, obesity).
3/7 Likely a rare immunodeficiency; estimate on TLR7 population data from gnomAD individuals: rare, highly conserved missense (~1:1000) and nonsense variants (~1:25,000).
