@SimonoffBob @Hawknest24 Hey! Check this out 👉 This paper proposes mechanisms by which #PMS may be part of a broader set of #infectious illnesses that are exacerbated by cyclic changes in immunosuppression, which are induced by cyclic changes in estrogen and progesterone: ncbi.nlm.nih.gov/m/pubmed/17468…
@SimonoffBob @Hawknest24 Our own team’s work has focused greatly on how nuclear receptors that control #hormone expression (like alpha-thyroid, VDR etc) also express key genes associated with the human immune response + innate immunity towards infection: microbeminded.com/wp-content/upl…
@SimonoffBob @Hawknest24 Here we show that VDR receptor expression changes during the #menstrual cycle - especially in the cycling endometrium 👉 That, in turn, alters how innate immune peptides under VDR control allow a woman’s body to manage infection/microbiome dysbiosis: ncbi.nlm.nih.gov/m/pubmed/19758…
@SimonoffBob @Hawknest24 All of the above (and similar trends) cld be impacted by traumatic #brain injury 👉 b/c it is well known that trauma to the brain can dysregulate the gut microbiome (via the gut-brain axis): frontiersin.org/articles/10.33…
@SimonoffBob @Hawknest24 Here’s another related study: grantome.com/grant/NIH/R21-…
@SimonoffBob @Hawknest24 This paper further hypothecizes how traumatic brain #injury could even have a profound impact on stability of the brain microbiome: sciencedirect.com/science/articl…
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