.@ICMRDELHI study on #plasmatherapy in #COVID19 pts initiated a debate. This thread collates experiences across India on the therapy starting with #Delhi Health Minister,@SatyendarJain. CM @ArvindKejriwal mentioned 1965 patients got befitted already. (1/n)
google.com/amp/s/www.ndtv…
Mr. Jain clarified that the @ICMRDELHI study doesn't say there are no benefits of plasma therapy, it says CPT may not be effective for a patient on ventilation. He said plasma therapy does not benefit those at stage 3 of the disease. But it helps those in stages 1 and 2. (2/n)
Doctors across Delhi shared their experiences in treating patients with plasma and commented that the therapy is bringing promising results in absence of a vaccine or other mode of treatment. (3/n)
timesofindia.indiatimes.com/india/despite-…
PGIMER will continue to administer plasma therapy to Covid-19 patients. Professor Pankaj Malhotra mentioned, "Rather than doing nothing, we can actually do something and try this therapy". (4/n)
hindustantimes.com/chandigarh/des…
According to the state administration, Odisha has established 6 plasma banks w/in a short span of 45 days and treated 692 patients. Official mentioned plasma therapy & dedicated COVID-19 care systems help Odisha cross the 1-lakh recoveries milestone. (5/n)
timesnownews.com/india/article/…
Plasma therapy has started in Jawahar Lal Medical College, Bhagalpur. Institute's principal pointed out that the therapy could save critically ill patients and those who have autoimmune disorders. (6/n)
timesofindia.indiatimes.com/city/patna/pla…
A case study from Nellore, #AndhraPradesh: 73 out of 82 critical Covid-19 patients underwent plasma therapy and recovered in Nellore district since August 5. One pt was a 55-year-old woman w/diabetes, high blood pressure, & kidney-related issues. (7/n)
newindianexpress.com/states/andhra-…
A nurse from Surat got recovered by plasma therapy along with standard treatment. She was ventilated for 3 days after her oxygen level fell drastically. (8/n)
timesofindia.indiatimes.com/city/surat/nur…
Speaking about the importance of plasma therapy in treating critically ill COVID-19 patients, the Health Minister, Assam stated that timely intervention with plasma therapy had shown good recovery among 368 such patients in Assam. (9/n)
sentinelassam.com/north-east-ind…
A 2-month old critically ill baby got recovered from plasma therapy in Nasik, Maharashtra. Nearly 70% of his lungs got infected during the time of admission. (10/n)
timesofindia.indiatimes.com/city/nashik/pl…
Global Literature in supporting the therapy:
The results from 10 severe adult cases showed that one dose (200 mL) of CP was well tolerated and could significantly increase or maintain the neutralizing antibodies at a high level. (11/n)
pnas.org/content/117/17…
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma revealed administration of convalescent plasma containing neutralizing antibody was followed by an improvement in clinical status. (12/n)
jamanetwork.com/journals/jama/…
A review of 5 studies reported (a) Convalescent plasma may reduce mortality in critically ill patients, (b) An increase in neutralizing antibody titers and disappearance of SARS‐CoV‐2 RNA was observed in almost all the patients after CPT therapy. (13/n)
ncbi.nlm.nih.gov/pmc/articles/P…
... and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. Based on the limited scientific data, CPT therapy in COVID‐19 patients appears safe, clinically effective, and reduces mortality. This review contains details of all 5 studies. (14/n)
The way forward: Like all other experimental therapies in treating #COVID19, convalescent plasma therapy also deserves to have experimented as positive outcomes also reported from several case studies. In this regard, the supervising doctors to take a call on case to case basis.
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