Thread by @ChrisMartey

The Gut #Microbiome is implicated in the pathogenesis of inflammatory arthritides & other health conditions

Gut dysbiosis is a broad term relating to an 'imbalance' of gut microbiota associated with an unhealthy outcome

I find this an interesting topic with several unknowns

🧵

"Gut inflammation is strongly associated with #Spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of subclinical gut inflammation in patients with #SpA."

nature.com/articles/s4158…

"Gut #Microbiome composition differs across regions and ethnicities, changes over time, and can be influenced by multiple factors, including, among others, diet, lifestyle, hormonal cycles, disease, comorbidity..."

'Gut microbiome in #Rheumatic diseases'
ard.bmj.com/content/80/11/…

There has been acknowledgement of gut dysbiosis in #RA too
nature.com/articles/s4158…

➡️ Alterations in microbial flora occurs in preclinical & established #RheumatoidArthritis

And here in, 'Intestinal Dysbiosis and #Rheumatoid Arthritis'
ncbi.nlm.nih.gov/pmc/articles/P…

This paper gives an excellent overview on the gut #Microbiome,

'The metabolic role of the gut #Microbiota in health and #Rheumatic disease: mechanisms and interventions'

nature.com/articles/nrrhe…

Via @NatRevRheumatol

There is also emerging evidence which makes reference to the gut #Microbiome and degenerative diseases such as #Osteoarthritis

1. rmdopen.bmj.com/content/5/2/e0…

2. link.springer.com/article/10.100…

Though more research is needed.

This paper explores the relationship between #Depression, skin #Psoriasis and the #GutMicrobiome

Coined the Gut-Brain-Skin Axis 🧠

sciencedirect.com/science/articl…

And what about ageing?

'Is inflammageing influenced by the #Microbiota in the aged gut? A systematic review'

sciencedirect.com/science/articl…

The links seem vast when considering gut inflammation and the #Microbiome

It'll be fascinating watching this body of evidence develop and how clinical practice will subsequently change.

For example, what role does #Exercise have to play?

This article poses some thoughts in relation to the role of #Exercise on the gut in older people with #Osteoarthritis

ncbi.nlm.nih.gov/pmc/articles/P…

I'd love to hear from clinicians who are confidently discussing gut health with their patients, especially those in #Rheumatology

Rosenbaum's work was my first insight into this topic

'The #Microbiome: a Revolution in Treatment for Rheumatic Diseases?'

pubmed.ncbi.nlm.nih.gov/27641915/