Ready for an #obesity #research disruptor?
@bcorkey 's studies on hyperinsulinemia and inflammation are a perennial favorite
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We often focus on slow or fast metabolism but there isn't enough talk on *energy efficiency*. See how much additional Δkcal is required (beyond that calculated) to effect 10% weight Δ: nejm.org/doi/full/10.10…
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"We ignore this important variable: involuntary control of energy metabolism" - @bcorkey
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Insulin resistance ↔️ Hyperinsulinemia ↔️ #Inflammation ↔️ #obesity
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ROS (inflammation) may be beneficial
- "ROS burns extra fuel" - data not shown (not yet published)
- ROS ↑ insulin secretion
- ROS ↑ in response to excess fuel and causes a leak to ↓ energy efficiency
5/
Is hyperinsulinemia the cause of #obesity ?
One study supports this with diazoxide reducing insulin levels, without changing glucose, resulting in #weightloss
academic.oup.com/jcem/article/8…
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Many of my patients who have insulin resistance/hyperinsulinemia wonder how GLP1s can help them if they ↑insulin secretion.
I have the smartest patients!
7/7
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