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IRB Barcelona Profile picture
@IRBBarcelona
Aug 22, 2019 • 6 tweets • 3 min read • Read on X
Existen diferencias en el grado de incidencia y supervivencia al cáncer entre hombres y mujeres. Sin embargo, sabemos poco sobre las causas moleculares de este hecho. Científicos👨‍🔬👩‍🔬del @IRBBarcelona han identificado en moscas posibles reguladores de este fenómeno
Sigue leyendo👇 Image
El laboratorio de División Celular, liderado por el investigador @icreacommunity Cayetano Gonzalez, comparó tumores cerebrales en moscas del vinagre, #Drosophila melanogaster, macho y hembra y observó que los tumores eran mas agresivos en los machos. Image
A continuación, compararon las células tumorales de machos y hembras e identificaron numerosas proteínas cuyos niveles eran mucho más abundantes en las células tumorales de machos. Varias de estas proteínas también están presentes en humanos. Image
Se centraron en la proteína Phf7, que está presente en células tumorales de moscas macho, donde el tumor es más agresivo, y ausente en células tumorales de hembras. Al eliminar Phf7 en machos, se reducía la agresividad del tumor, llegando a niveles similares a los de las hembras. Image
Los resultados muestran que se pueden regular las proteínas responsables de las diferencias en tumores entre machos y hembras para reducir el grado de malignidad que está asociado al sexo del individuo afectado.
Comprender las bases moleculares de las diferencias en incidencia y supervivencia al cáncer entre hombres y mujeres es importante para encontrar tratamientos específicos y más efectivos
Lee más sobre este estudio publicado en
@ScienceAdvances
en el link👇irbbarcelona.org/es/news/identi…

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More from @IRBBarcelona

IRB Barcelona Profile picture
Apr 25, 2022
🔬An international consortium, led by #IRBBarcelona & the biotech company @MerusNV, reports the discovery of MCLA-158, the first clinical candidate screened in #organoids targeting 🎯 #cancer #stemcells of solid tumors.

📰@NatureCancer

➡️bit.ly/3MLiu3h

#IRBScience Image
Named Petosemtamab, the antibody MCLA-158 prevents the onset of #metastasis (that is, the spread of #cancer to other vital organs) and slows the growth of primary tumours in experimental models of cancer. Image
The study also lays the groundwork for the use of #organoids in the #DrugDiscovery process undertaken by pharmaceutical companies.

Organoids are patient-derived samples that can be grown in the laboratory, and they reproduce certain aspects of the tumour compartment. Image
Read 6 tweets
IRB Barcelona Profile picture
Sep 22, 2020
#IRBScience: Published in @GenomeMedicine, the latest work from the SBNB lab points to the co-occurrence of #cancer driver genes as a key to precision medicine.

Read👓the news➡️bit.ly/2RP3WFf

(1/4) Follow this thread to learn more ↘️
#WorldCancerResearchDay
The system is called Targeted Cancer Therapy for You (TCT4U), and it's aimed at predicting tumour response to different treatments.💊

It has allowed the identification of a set of complex biomarkers🧬that have now been made available to the medical-scientific community.

(2/4)↘️
"The sum of two or more mutated #Cancer driver genes affects the tumour's response to treatments" says @ptck72, "through this work, we see that studying cancer driver genes as a whole can bring about a great advance towards precision medicine".

#WorldCancerResearchDay
(3/4)↘️
Read 4 tweets
IRB Barcelona Profile picture
Sep 21, 2020
Today is #WorldAlzheimersDay 🧠 and this disease has been on #IRBBarcelona's agenda since its start.

@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)
In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.

➡️bit.ly/3clhW34
#IRBScience #WorldAlzheimersDay
(2/4)
In fact, the @ShorterLab, one of the 🔝groups in protein aggregation, published a review on their work in @TrendsNeuro.

➡️cell.com/trends/neurosc…
#WorldAlzheimersDay
(3/4)
Read 4 tweets
IRB Barcelona Profile picture
Sep 7, 2020
The Evomet project, coordinated by #IRBBarcelona, will train future leaders in metastasis research.

Read the news➡️bit.ly/324VEid

Follow this thread to meet the labs participating⬇️
(1/9)
At @IRBBarcelona, the Growth Control and Cancer Metastasis lab, led by @RogerGom1, will be hosting two students.
irbbarcelona.org/en/research/gr…

@MarionaGraupera will also mentor two students in the Vascular Signaling Lab, which she leads at @idibell_cat. procure-ico.eu/mariona-graupe…
(2/9)
At @IMPvienna, @obenaufa will be training one of the future leaders in metastasis research, in the Obenauf lab obenauflab.com

A position is available alongside @ClareIsacke, Head of the Molecular Cell Biology team at @ICR_London.
icr.ac.uk/our-research/r…
(3/9)
Read 9 tweets
IRB Barcelona Profile picture
Sep 4, 2020
@IRBBarcelona coordinates the European Project Evomet to train 15 young scientists and future leaders in metastasis research with the aim to identify therapeutic solutions. The project has received €4 M and will last for four years.

irbbarcelona.org/en/news/irb-ba…
At Evomet also participate: @idibell_cat idibell_cat @imperialcollege @BreastCancerNow @idibaps @unil
@Cambridge_Uni @GustaveRoussy @ULBruxelles
@UniBasel_en @Boehringer @intomics @ChromaCure
Each of the institutions will host one of the selected young researchers and will train them until they complete their doctorate, except for @IRBBarcelona and @idibell_cat IDIBELL, which will host two predoctoral researchers each.
Read 4 tweets
IRB Barcelona Profile picture
Aug 17, 2020
#IRBScience: The @bbglab publishes "A compendium of mutational cancer driver genes" in @NatureRevCancer, with mportant implications in clinical decision making.

📢568 genes identified with the potential to trigger #cancer!

➡️bit.ly/2DUxvSn
(1/5) @nlbigas @fran_mj88
The study stands on the analysis of the genomes of 28,000 tumours from 66 types of cancer and it's a major update of the #IntOGen platform (intogen.org), aimed at identifying mutational cancer driver genes.

(2/5)
“The compendium of driver genes provides cancer researchers, both in the clinical and basic research setting, with crucial knowledge and it has an important impact on clinical decision-making,” says @nlbigas, head of the @bbglab at @IRBBarcelona and @icreacommunity.

(3/5)
Read 5 tweets

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