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Lonnie R Marcum, PT, BSHCA Profile picture
@LonnieRhea
Sep 22, 2019 • 13 tweets • 10 min read • Read on X
Jayakumar Rajadas, PhD @StanfordMed | use of Disulfiram for the treatment of unresolved Lyme infections and associated detrimental host immune response. A silver bullet? #LivLymeSummit @liv_lyme Image
@StanfordMed @liv_lyme Rajadas | Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening. #LivLymeSummit ncbi.nlm.nih.gov/pmc/articles/P…
Rajadas | giving a nice thank you to his collaborators. Funding by @liv_lyme & @BayAreaLyme Zhang @JohnsHopkinsSPH Embers @Tulane, Kenneth Liegner, MD & others. #LivLymeSummit Image
@liv_lyme @BayAreaLyme @JohnsHopkinsSPH @Tulane Rajadas | minimally 10-20% of Lyme patients develop a chronic, painful condition. It is very real. It affects the heart, the joints and the nervous system. #LivLymeSummit
@liv_lyme @BayAreaLyme @JohnsHopkinsSPH @Tulane Rajadas | Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains. #LivLymeSummit jneurosci.org/content/38/50/…
Rajadas | these Borrelia burgdorferi lipopeptide aggregates cause inflammation in the brain. #LivLymeSummit ImageImage
Rajadas | Screening of NCI-DTP library to identify new drug candidates for Borrelia burgdorferi. #LivLymeSummit nature.com/articles/ja201…
Rajadas | Currently conducting mouse trial with Disulfiram. Acting as an bactericidal. Effects all these components of B.b. 👇 #LivLymeSummit Image
Rajadas | "Disulfiram is a simple molecule, as simple as asprin" "I like Disulfiram because it is not an antibiotic and will not destroy the microbiome." "Disulfiram is dangerous around alcohol, and alcohol is found everywhere [handwash, foods, meds, etc]" #LivLymeSummit
Rajadas | Finding Disulfiram has
bactericidal activity against Borrelia persister cells. (Also appears to have activity against Bartonella & Babesia) Unlike Doxycycline which is bacteriostatic. #LivLymeSummit Image
Rajadas | Also testing Azlocillin sodium in the lab. Seeing 100% kill of all phases of Borrelia in the laboratory. #LivLymeSummit
Rajadas | List of full antibiotics tested. Disulfiram was best in the mouse model. #LivLymeSummit ImageImage
Rajadas | IN SEARCH OF A CURE FOR LYME DISEASE: THE DISULFIRAM STORY by @BonnieCrater @BayAreaLyme
bayarealyme.org/blog/in-search…

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More from @LonnieRhea

Lonnie R Marcum, PT, BSHCA Profile picture
Jun 3, 2022
@Lymenews The largest study, on which the CDC based its recommendation, showed one thing—a single dose of doxycycline reduced the incidence of rash in a small group of people. That’s it. (Nadelman 2001) 2/
@Lymenews End point: "Erythema migrans occurred at the site of the tick bite in 8 of the 247 subjects in the placebo group (3.2 percent), as compared with 1 of the 235 subjects in the doxycycline group (0.4 percent, P<0.04)" Seven fewer rashes! nejm.org/doi/10.1056/NE…
@Lymenews The ticks in the Nadelman study were identified by an entomologist. As the authors pointed out, patients and clinicians are not skilled at distinguishing I. scapularis from other ticks and arthropods, and even from scabs or debris. (Sood 1997) 4/
Read 22 tweets
Lonnie R Marcum, PT, BSHCA Profile picture
Jul 12, 2021
New | Lyme arthritis: linking infection, inflammation and autoimmunity. #LymeDisease (a thread) 1/
nature.com/articles/s4158…
"In the USA, B. burgdorferi often disseminates in the blood during the first few weeks of infection in a process that requires the binding of Borrelia surface adhesins to host integrins on the vascular endothelium28–30. " 2/ Image
"As shown in mice, the spread of B. burgdorferi through the vasculature or lymphatics is dependent on the inter-actions of spirochaetal surface molecules and endothe-lial cell membrane proteins." 3/
Read 29 tweets
Lonnie R Marcum, PT, BSHCA Profile picture
Feb 3, 2021
Thread: A major barrier to progress in understanding the neurologic manifestations of #LymeDisease has been a lack of a tractable laboratory animal model to evaluate the mechanisms of central nervous system pathogenesis.
For decades we have seen study after study of Lyme arthritis. As it turns out the most frequently reported Lyme symptoms are neurological symptoms: memory loss and cognitive impairment, sleep impairment, psychiatric manifestations, headaches, neuropathy and more. 2/
This is the first study, to my knowledge, that shows how Borrelia burgdorferi gets into the central nervous system, how the immune system responds, and how the bacteria adapt to the immune system. #Lyme
Meet the researcher Catherine Brissette, Ph.D. globallymealliance.org/meet-researche…
Read 15 tweets
Lonnie R Marcum, PT, BSHCA Profile picture
Sep 23, 2020
In an encouraging development yesterday @CDC_NCEZID representative Ben Beard made an important announcement--a new "national strategy" for vector-borne diseases. I'll explain in a thread 1/n
lymedisease.org/framework-vect… via @Lymenews
The Kay Hagan Tick Act, passed in 2019, called for @hhs to develop a national strategy to address issues related to vector-borne diseases. The Lyme community fought hard for the passage of the #TICKact lymedisease.org/tick-act-appro… via @Lymenews 2/
The idea was for @HHSGov to co-ordinate with other federal agencies and departments, including the @CDCgov @EPA @US_FDA @NIH @DeptofDefense @USDA @USGS and others, to get everybody working towards the same goals. 3/ Image
Read 12 tweets
Lonnie R Marcum, PT, BSHCA Profile picture
Aug 9, 2020
The geothermal features in Yellowstone are amongst my top 10 favorite sites on this planet. Here’s a bit of #microbio history on the PCR test I’d like to share.
Pictured: Grand Prismatic at the Midway Geyser Basin @YellowstoneNPS
“Until the 1980s, our ability to study DNA was limited. Things we take for granted today such as DNA fingerprinting to identify criminals, DNA medical diagnoses, DNA-based studies of nature, and genetic engineering did not exist.”
“But in 1985, the polymerase chain reaction (PCR) was invented. PCR is an artificial way to do something that living things do every day—replicate DNA. PCR is the rocket ship of replication, because it allows scientists to make billions of copies of a piece of DNA in a few hours.
Read 7 tweets
Lonnie R Marcum, PT, BSHCA Profile picture
Jun 26, 2020
What has the #Lyme community learned from the #COVID19 pandemic?
thread...
lymedisease.org/bureaucratic-d…
(1) In a matter of weeks, the federal government can allot trillions of dollars to one disease.
2) In a matter of weeks, the @CDCgov can develop and mass produce a new test.
Read 6 tweets

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