IL11 signaling in fibroblasts in IPF biorxiv.org/content/10.110…. Follow up on a recent report on IL11 as a therapeutic target for IPF (stm.sciencemag.org/content/11/511…) - the original had good human data and some nice mouse models. @stuartacook1 #Immunology #Fibrosis
This preprint dissects out the signaling with a floxed IL11RA1, conditionally deleted in fibroblasts. This drives basically the entire phenotype, and there are striking reductions in fibrosis in the fibroblast-KO mice. There’s also substantially lower inflammation.
I’d like to see some earlier timepoints looking at the inflammation, since the earliest immunophenotyping looks like day 14 - after major damage has already started. It’d also be interesting to try inducible deletion of IL11RA1 after initial bleomycin administration.
Combined with the STM paper, this is very solid data on a role for IL11 in fibroblasts driving a pro-fibrotic response, and fibroblast inflammation / immune cross-talk early on. IPF needs more therapeutic options, so I look forward to more translation on this pathway.
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