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Detailed info here on symptoms and infectivity of the #CoronavirusOutbreak @TheLancet. Disturbing scenes in this @nytimes video. See next tweets for more info. #coronavirus #WuhanOutbreak
tinyurl.com/qw4r2a9
tinyurl.com/sf4wv9n
Here are screenshots from the informative @TheLancet article detailing the virus, symptoms, and evidence for person-person transmission, now seemingly occurring even before symptoms occur. Related to Bat SARS and CoV. #coronavirus. tinyurl.com/qw4r2a9 ImageImage
Thanks to a follower for pointing out that resveratrol & related stilbene derivatives have been shown to inhibit replication of SARS & nucleocapsids of MERS coronaviruses in cell culture, exact mechanism not yet known tinyurl.com/rtjdv6h tinyurl.com/s7ynxns #virusoutbreak
Looks like it came from a bat. In Lifespan’s Ready for the Worst, I explain why the biggest threat to civilization is a viral outbreak & what it could be like. See Moving Faster & Age of Inoculation, for how tech available now, eg Arc-Bio.com, could combat outbreaks. Image
Link is ArcBio.com
NYT video compendium is behind paywall. You can see some of the publicly available videos here:


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David Sinclair, PhD
@davidasinclair
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
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David Sinclair, PhD
@davidasinclair
1/ Let me start by saying that this was a fantastic piece on vaccine development by @stuartathompson at @NYTimes.
2/ Having started a now public company that makes vaccines (thanks to my cofounder Darren Higgins and to @gatesfoundation), I can tell you many people don't appreciate just how long it takes to develop a drug.
3/ Vaccines often take longer. Of every drug that is picked to go into humans, less than 5% will ultimately be approved. Luckily, the outbreaks of SARS and MERS in 2004 and 2012 have given us a head start (SARS and SARS-CoV-2 are ~80 percent identical).
Read 7 tweets
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David Sinclair, PhD
@davidasinclair
Outlook for this decade: POOR
1. 85% of economic impact is caused by fear of the virus not by stay-at-home. 2. WHO says the virus may never leave, like HIV. If true, we are in serious trouble. 1/n
Let’s not ignore the likelihood that survivors “will be left with chronic kidney & heart problems”, something the pro-herd immunity folks don’t consider. If you think spending 17% of US GDP on healthcare is bad now...2/n
We have also seen that leadership matters. NZ & Australia stopped movement, enforced it & tested and traced asymptomatics. They couldn’t even buy a coffee & are now essentially covid-free. US & Britain waited, let people travel & didn’t test & trace. We see the consequences. 3/n
Read 6 tweets

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