Thank Dr. Jankelosn for replying my email about the dosage regimen used in this study: QT intervals & HCQ+Azi in treating #Covid_19
medrxiv.org/content/10.110…
🔸#HydroxyChloroquine 400mg BID on day 1 followed by 200mg BID for 4 days, plus Azithromycin 500md x1 for 5 days
medrxiv.org/content/10.110…
🔸#HydroxyChloroquine 400mg BID on day 1 followed by 200mg BID for 4 days, plus Azithromycin 500md x1 for 5 days
🔸Baseline QT intervals: ~435
🔸11% of patients QT increased to >500ms
🔸Creatinine and renal function are significantly important factors for QT prolongations.
🔹The QT intervals were increasing daily, which seems to be related to the elevating blood concentrations of HCQ
🔸11% of patients QT increased to >500ms
🔸Creatinine and renal function are significantly important factors for QT prolongations.
🔹The QT intervals were increasing daily, which seems to be related to the elevating blood concentrations of HCQ
The blood concentration of HCQ would reach the highest on the last day after continuous administration.
In this study, HCQ was administered for 5 consecutive days.
As you can see in the figure, the QT intervals prolonged most on Day 5.
In this study, HCQ was administered for 5 consecutive days.
As you can see in the figure, the QT intervals prolonged most on Day 5.
