🔸13 patients, average weight=82.7 kg
🔸46% pts BMI>30
🔸12 on mechanical ventilators
🔸1 on ECMO
🔸30.7% with medium/severe renal dysfunction
🔺In this D regimen, the average HCQ dose is ~7.5 mg/kg/day, which is above the well established safe upper limit: 6.5 mg/kg/day; meanwhile, the HCQ blood concentration exceeds the upper safe level: 2mg/L.
🔸In conclusion, considering efficacy and safety, 800mg Qd as a loading dose on 1st day, then 400mg/day Qd for 4-6 days is the optimal dosage regimen for HCQ to treat #COVID2019
🔸 Dosage should be further individualized to WEIGHT, renal and heart condition, etc