Thread by @Tony_Calles

🦠 #COVID19 & #Cancer🧬
⚠️Preliminary information from our own experience in lung cancer patients with #COVID19. #LCSM #OncoAlert
So far n=20 with SARS-CoV-2 confirmed by PCR.
🧶 Thread 👇

📊But first, quick poll: How many lung cancer patients with #COVID19 have you already attended?

🔎Expected demographic distribution reflecting our regular clinical practice.
Mean age 65 yo; pathology: 63% ADK, 21% SqCC, 11% SCLC; Stage IV 79%, III 16%, I-II 5%.
Prevalence of men (84%) in infected but without apparent differences by gender in mortality.

💊16% were receiving chemotherapy, 26% immunotherapy, and 21% were pending on treatment initiation (recently diagnosed lung cancer patients). Low numbers for TKI. Additionally, 16% on surveillance w/o Rx.

So, it is probably IO does not seem to protect against SARS-CoV-2 infection, and those patients who have become infected without treatment would most likely got infected in the hospital during previous diagnostic tests, visits, etc. vs community (⁉️)

🏥69% of lung cancer patients required admission, which is very high. 26% of patients had no associated pneumonia (most by chest X-ray). Only 5% with pneumonia did not required admission (& cured)

We have a 37% mortality rate, which confirms the vulnerability of these patients.

Among the patients who died due to #COVID19, they tend to be more stage IV and adenocarcinoma histology compared to those cured. Furthermore, they were more on active systemic treatment than those who survived #COVID19 (71% vs. 42%), which suggests either

a deleterious effect of the treatment or simply the need for treatment due to a more advanced disease. There does not seem to be an excess risk of mortality by type of systemic treatment except for chemotherapy, but these are very low numbers, very few patients.

Disclaimer (1/2): This is work in progress. Note we don’t take into account suspected cases. Please, use this data only as informative as this may change with more cases and further follow up. Also consider the epidemiology of #COVID19 in your area as this may not reflect others.

📈Larger numbers are needed for statistical considerations and this is why we don’t present any test here. We are collaborating in a national-wide registry, an enormous effort lead by the @gecp_org group. This will ultimately help to understand #COVID19 in lung cancer #lcsm(2/2)

Credit to Dr. Rosa Alvarez @rosaalvarezal, Dr. Mar Galera, Dr. Manuel Alva @malva_91, and Dra. Inmaculada Aparicio who are the staff and med onc residents behind this collective effort attending #COVID19 & #lungcancer patients in this pandemia in our hospital. #SomosElMarañon🏥

🙏Thanks for reading #lcsm
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