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Apr 29, 2020 6 tweets 4 min read Read on X
NEW Research—First randomised trial of #remdesivir for hospitalised patients who are critically ill with #COVID19 suggests antiviral drug is not associated with significant clinical benefits vs placebo: study of 237 adults from 10 hospitals in Wuhan (1/5) hubs.ly/H0p-BMJ0 Image
Authors note that the study was stopped early by the data safety monitoring board because of difficulty recruiting patients after the #COVID19 outbreak in Wuhan, China was brought under control & more research is needed (2/5) Image
While not statistically significant, pre-specified secondary outcomes found that time to clinical improvement & duration of invasive mechanical ventilation were shorter in people treated with remdesiver within 10 days of showing symptoms, compared with standard care (3/5) ImageImage
In a Comment, John Norrie "Absence of statistical significance in an underpowered trial means that the findings are inconclusive. The particular challenges of delivering pandemic trials underline the importance of data sharing, allowing rapid curation of relevant datasets" (4/5) Image
Prof John Norrie continues "Promising signals from observational data must be rigorously confirmed or refuted in high-quality randomised trials—particularly given that for #COVID19 no proven safe and effective treatments yet exist" (5/5) hubs.ly/H0p-zTg0
Full Article and linked Comment also available below:

#Remdesivir in adults with severe #COVID19: a randomised, double-blind, placebo-controlled, multicentre trial: thelancet.com/lancet/article…

Remdesivir for COVID-19: challenges of underpowered studies thelancet.com/lancet/article…

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More from @TheLancet

Mar 24, 2023
World TB Day 2023.

“Another year of both progress and setbacks for tuberculosis research and control efforts”, write @LancetRespirMed editors.

We begin this #WorldTBDay thread with an Editorial 🧵 hubs.li/Q01J2k780
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Mar 23, 2023
‘Policy inertia’ is enabling the products and practices of some commercial actors to cause significant, ongoing harm to health, warn experts.

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Sep 14, 2022
New Lancet Commission details "massive global failures" of the #COVID19 response & issues recommendations to help:
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Access the report: hubs.li/Q01mlD0h0 The Lancet COVID-19 Commission card. Image credit: Boris SV/
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Sep 13, 2022
📢 The Lancet Group is pleased to announce an important step towards advancing equity, diversity, & inclusion in our publishing practices:

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Apr 7, 2022
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