On this day, in 1981, 5 cases of what came to be known as AIDS, were reported in @CDCMMWR—changing the world.
Today, the Lancet journals reflect on the science and people behind #40YearsOfHIV/AIDS response through a special collection of content ➡️ hubs.li/H0PGLbC0
Months later, Kenneth Hymes et al. published an article in @TheLancet describing Kaposi's sarcoma in a group of young homosexual men in New York, suggesting a sexually transmissible disease might have a role in the pathogenesis of the rare cancer.
Nociplastic pain is a new descriptor of pain arising from abnormal pain signal processing. It applies to a range of conditions, such as fibromyalgia, that lack clear mechanisms or biomarkers—a challenge to diagnose and treat.
In 2019, the no. of smokers worldwide ⬆️ to 1.1 billion. Tobacco smoking caused ~8 million deaths—1 in 5 male deaths.
#GBD studies of 204 countries highlight the enormous health toll of 🚬 and authors urge all countries to do more to ⬇️ tobacco use. See hubs.ly/H0Pd0590.
89% of smokers began by age 25—evidence suggests an individual is unlikely to become a smoker if they do not start by this age.
Yet over half of countries show no progress in reducing 🚬 among 15-24-year-olds—a critical window to prevent initiation. Read hubs.li/H0Pd09f0.
Why have 🚬 control policies had little impact on young people? They may respond to policies in different ways to adults, writes @aekunst in @TheLancetPH. The solution? Centralising young people's perspectives and experiences. Read hubs.li/H0Pd0YM0.
Migraine affects over 1 billion people worldwide, is the 2nd leading cause of disability, and a major source of losses to the 🌍 economy—yet professional and political awareness is lacking. Read a new @TheLancet Series on #Migraine by @MessoudAshina et al. hubs.li/H0J-73-0
In 2011, migraine cost Europe an estimated €50-€111 billion. Evidence suggests primary care could meet the needs of most #migraine patients, where available. Read an overview of migraine epidemiology, global burden, and migraine care challenges. hubs.li/H0J-73-0
Migraine diagnosis is based on clinical criteria—criteria that do not capture migraine’s heterogeneity. Read about recent progress in disease characterisation, biomarkers of #migraine, and precision medicine for affected patients: hubs.li/H0J-73-0
Maternal & child undernutrition remains a major health concern—the last decade saw little progress despite proven interventions & recent gains may be offset by #COVID19. A follow-up #LancetNutrition Series calls for global recommitment.
Previously highlighted interventions continue to be effective at reducing stunting, micronutrient deficiencies & child death. Delivering nutrition interventions within the #first1000days of life if key.
NEW—COVID-19 causes more severe disease than seasonal influenza, confirms a Study of French national data from over 130,000 hospitalised patients published today in @LancetRespirMed: hubs.li/H0CRd__0 (1/4)
Nearly twice as many people were admitted to hospital for COVID-19 at the height of the pandemic than were for influenza at the peak of the 2018/2019 flu season; (COVID-19, 89,530 patients vs influenza, 45,819 patients) (2/4)
The death rate among COVID-19 patients was almost three times higher (number of deaths: COVID-19 15,104/89,530 [16.9%] vs influenza 2640/45,819 [5.8%]), and a greater proportion of COVID-19 patients experienced severe illness requiring intensive care. (3/4)
Designed in 1948, the #NHS pay structure has not kept up with the changes in women’s position in society. The medical #genderpaygap in England has worsened as a result of #COVID19, and does not narrow until aged 65. Jane Dacre et al. Comment: hubs.li/H0CHQfJ0
A recent review shows that the total medical #genderpaygap in England is 24·4% for hospital doctors, 33·5% for general practitioners, and 21·4% for clinical academics.
A severe reduction in child-care provision during the #COVID19 pandemic will have disproportionately stalled the careers of women in medicine; it is likely that most accommodations to adjust to the shortage of child-care will have been made by female doctors.
NEW—First full results from interim analysis confirm that the Oxford #COVID19 vaccine is safe and efficacious against symptomatic COVID-19 disease: hubs.li/H0CcSs60 (1/6)
The vaccine protects against symptomatic disease in 70% of cases – with vaccine efficacy of 62% for those given two full doses, and of 90% in those given a half then a full dose. (2/6)
The first clinical efficacy results of the vaccine are based on a pre-specified pooled analysis of phase 3 trials in UK and Brazil (11,636 people), alongside safety data from 23,745 participants in 4 trials in the UK, Brazil and South Africa. (3/6)
NEW—Radiotherapy following prostate cancer surgery can safely be avoided for many men: finding from a prospectively planned systematic review & meta-analysis assessing results from 2153 men enrolled across 3 trials, with median follow-up of at least 5 yrs hubs.li/H0x3LxP0
NEW—Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial hubs.li/H0x5PXH0 (Trial 1/3)
NEW—Adjuvant radiotherapy vs early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial @TheLancetOncol (Trial 2/3) hubs.li/H0x69kT0
NEW Editorial discusses the enormous effect that #COVID19 has had on scientific publishing as well as the increased public interest in & scrutiny of research & science hubs.li/H0wwv5L0
In recognition of #PeerRevWeek20 we would like to say thank you to our reviewers for their essential role in maintaining the advancement of science and medicine through helping us to identify the most robust and impactful work #TrustInPeerReviewhubs.li/H0wB2cg0
From peer review, through our in-house editing process, production, to publication and beyond, the entire Lancet team brings a wealth of expertise in scholarly publishing
Non-communicable diseases & injuries (NCDI) cause more death & disability at every age among the world’s poorest billion than in wealthy countries— new @NCDIpoverty Commission provides cost-effective & equitable interventions to address #NCDIPovertyhubs.li/H0wd1XP0
Among the world’s poorest people, almost 800,000 under age 40 die each year from #NCDs & injuries
"Partnerships & coalition building will be key not only within the #NCD community but also in alliances forged with the UHC & anti-poverty movements"—The Lancet Editors reflect on the #NCDIPoverty Commission calling for expansion of the global NCD agenda hubs.li/H0wfQsN0
New research mapping global trends in vaccine confidence across 149 countries between 2015-19 & based on data from over 284,000 adults surveyed about their views on whether vaccines are important, safe and effective, reveals vaccine hesitancy hotspots hubs.li/H0w0gKb0
Findings from largest study of global vaccine confidence to date finds that although confidence remains low across Europe, there are signs that it is increasing for much of Europe, including France hubs.li/H0w0gKb0
Largest global vaccine confidence survey suggests that overall confidence in vaccines—including safety, effectiveness, and importance—fell in Indonesia 🇮🇩, the Philippines 🇵🇭, Pakistan 🇵🇰, and South Korea 🇰🇷 between Nov 2015 and Dec 2019 hubs.li/H0vXTbc0
NEW Modelling—Current projections point to an estimated 3.1 billion population lacking effective UHC coverage in 2023, with nearly a third residing in south Asia: finding from #GBDStudy 2019 Universal Health Coverage Collaborators @IHME_UWhubs.ly/H0v8_6k0
"The paper also raises some fundamental questions about the relevance of this approach to measuring UHC progress at this moment in time"
The universal health coverage ambition faces a critical test—Comment on #GBDStudy from M Kruk, J Ataguba & P Akweongo hubs.ly/H0vcH0y0
NEW—40% of #dementia cases could be prevented or delayed by targeting 12 risk factors throughout life: finding from 2020 update to @TheLancet Commission on dementia prevention, intervention, and care #AAIC20hubs.ly/H0s-v8_0
NEW—In some countries, the proportion of older people with dementia has fallen, probably due to improvements in education, nutrition, & lifestyle, showing possibility of reducing #dementia through preventative measures: @TheLancet Commission update #AAIC20hubs.ly/H0s-v8_0