World TB Day 2023.

“Another year of both progress and setbacks for tuberculosis research and control efforts”, write @LancetRespirMed editors.

We begin this #WorldTBDay thread with an Editorial 🧵 hubs.li/Q01J2k780 Tuberculosis (TB) remains one of the world’s deadliest—yet preventable and curable—infectious killers.

In 2021, 1.6 million deaths were caused by the disease, and a further 10.6 million people fell ill with TB. #EndTB

‘Policy inertia’ is enabling the products and practices of some commercial actors to cause significant, ongoing harm to health, warn experts.

A new Lancet Series argues for a bold system overhaul that puts people and planet first: hubs.li/Q01HD8h_0 What are the commercial determinants of health?

Lack of consensus on the definition has been a sticking point, hampering action.

The Series authors provide an explanation and outline potential pathways to health benefits or harms: hubs.li/Q01J2gbV0

New Lancet Commission details "massive global failures" of the #COVID19 response & issues recommendations to help:
1️⃣ End the pandemic emergency
2️⃣ Protect against future health shocks
3️⃣ Achieve sustainable development for all
Access the report: hubs.li/Q01mlD0h0 Glaring deficiencies in pandemic preparedness & response have cost lives, livelihoods, & progress towards the #SDGs.

The Lancet COVID-19 Commission identifies several failures of governance ⤵ hubs.li/Q01mmNZd0

📢 The Lancet Group is pleased to announce an important step towards advancing equity, diversity, & inclusion in our publishing practices:

Authors & reviewers will now be invited to (optionally) self-report their gender, race, & ethnicity via our Editorial Manager sites. 1/4 Understanding the demographics of our authors & reviewers is integral to the work of the Lancet Group for Racial Equity (GRacE) & the Gender & Diversity Taskforce; to identify gaps in representation & propose solutions to address them. 2/4

An estimated 13 million deaths a year are due to avoidable environmental causes.

On #WorldHealthDay, here's evidence on the link between human & planetary health to inspire stronger, whole-of-society action ⤵️ Since 2016, @LancetCountdown has been tracking key indicators of the impacts of climate change on health worldwide.

The 2021 report painted a bleak picture—code red for health: hubs.li/H0ZNzkk0

#LancetClimate21 #WorldHealthDay

Strengthened primary health care (PHC) could be our ticket to universal health coverage.

But only with the right financing arrangements.

New @LancetGH Commission outlines ways to #FinancePHC, placing people & equity at the
centre ➡️ hubs.li/Q017p3NK0 When successfully delivered, primary health care can:
1⃣ Improve equity, promote good health, & reduce risk of disease
2⃣ Limit the financial burden of health-care for households
3⃣ Save governments money

👉 hubs.li/Q017p3NK0 #FinancePHC

"The importance of changing long-standing widespread attitudes about the role of women in society cannot be overstated."

This #InternationalWomensDay, leaders must make good on commitments to uphold & advance the rights of women everywhere.

#IWD2022 #LancetWomen This new @IHME_UW study reveals the adverse social & economic effects of the #COVID19 pandemic on women—especially in low-resource settings & among underrepresented populations ⬇️

#IWD2022 #GenderEquity hubs.li/Q015zCkP0

Across the world, women are leading efforts to advance health and equity.

Ahead of #InternationalWomensDay, be inspired by the lives and work of women we have recently profiled ⬇️

#IWD2022 #LancetWomen "Rani Bang's dedication has helped millions of adolescents, youth, and women take charge of their own bodies and their health."

Rani Bang—leader in women's reproductive health #IWD2022 hubs.li/Q015skfP0

Today is #WomenInScience day!

Discover the remarkable life stories & work of the women featured in The Lancet this year 👇 Ayoade Alakija has never been motivated by career goals; her work is about making a difference to people's lives.

Meet the newly appointed @WHO Special Envoy & Co-Chair of the Access to #COVID19 Tools Accelerator.

@yodifiji #WomenInScience hubs.li/Q013Z78G0

Increasing overmedicalisation at the end of life is denying people & their families a good death.

Towards a compassionate community model: The Lancet #ValueofDeath Commission calls for a radical rethink of care for the dying & attitudes to death. hubs.li/Q0139HH30 How death is managed today:
• Alienates communities
• Pushes families in countries without #UHC into poverty
• Deprioritises efforts to reduce suffering, such as #PalliativeCare
• Diverts resources
• Is costly for health services
#ValueofDeath hubs.li/Q013dcwv0

.@naomiclarelee opens the #GHFutures2030 Commission launch.

"'Digital Health is not neglected—it's a distraction to #UHC', we were told. Now, we're in a pivotal moment—being intentional about this new path is essential & requires urgent improvement." @GHFutures2030

https://twitter.com/TheLancet/status/1452402124411838469

"People are much more aware of how we depend on digital transformation...to resolve & respond to health challenges. But, we are also more aware of the ways these transformations—or exclusion from them—can be detrimental to our health & rights." 💬 @IlonaKickbusch #GHFutures2030

Insulin—one of the greatest medical achievements of all time. Yet, its centenary year is marred by persisting inequity in access.

@TheLancetEndo continues to highlight 100 years of #insulin: hubs.li/H0XTQ390

Explore the NEW #Insulin100 content 👇 Type 1 #diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell mass.

This Review highlights advances and challenges in regenerative medicine approaches to restoring β-cell mass and function: hubs.li/H0XT_T90 #Insulin100

100 years ago, #insulin was discovered—today, it is inaccessible for millions.

The Lancet journals reflect on this life-saving treatment and the "golden opportunity to improve access to insulin and #diabetes care" the centenary represents: hubs.li/H0Rp3p40 #Insulin100⬇️ The discovery of insulin ranks among the leading triumphs of medical research, with effects on #endocrinology, #medicine, and society that reverberate 100 years later.

Track "the birth of an idea" in @TheLancetEndo, by Robert Hegele and Grant Maltman: hubs.li/H0Rbx1D0

There are some 26.3 million refugees worldwide today.

On #WorldRefugeeDay, the Lancet journals highlight the health insecurity and inequities refugees face, exacerbated by the #COVID19 pandemic ⬇️

#WithRefugees Applications for asylum and resettlement disrupted, blamed for spreading #COVID19, and inequitable #vaccine access.

Under the 1951 Refugee Convention, refugees are entitled to certain protections—our Editorial questions whether these are being upheld. hubs.li/H0QDCzT0

On this day, in 1981, 5 cases of what came to be known as AIDS, were reported in @CDCMMWR—changing the world.

Today, the Lancet journals reflect on the science and people behind #40YearsOfHIV/AIDS response through a special collection of content ➡️ hubs.li/H0PGLbC0 Months later, Kenneth Hymes et al. published an article in @TheLancet describing Kaposi's sarcoma in a group of young homosexual men in New York, suggesting a sexually transmissible disease might have a role in the pathogenesis of the rare cancer.

Read hubs.li/H0PGMwN0.

#ChronicPain affects over 30% of people worldwide and exerts an enormous personal and economic burden.

A new @TheLancet Series on #ChronicPain presents recent findings across specialties, with implications for health care providers and patients: hubs.li/H0PgfvK0

Thread⬇️ The Series explores 3 types of pain—nociceptive, neuropathic, nociplastic—and the biopsychosocial model of pain—interactions between #chronicpain, biological, psychological, and social factors.

Read an update on burden, best practices, and new advances: hubs.li/H0Pgfv10

In 2019, the no. of smokers worldwide ⬆️ to 1.1 billion. Tobacco smoking caused ~8 million deaths—1 in 5 male deaths.

#GBD studies of 204 countries highlight the enormous health toll of 🚬 and authors urge all countries to do more to ⬇️ tobacco use. See hubs.ly/H0Pd0590. 89% of smokers began by age 25—evidence suggests an individual is unlikely to become a smoker if they do not start by this age.

Yet over half of countries show no progress in reducing 🚬 among 15-24-year-olds—a critical window to prevent initiation. Read hubs.li/H0Pd09f0.

NEW—Emerging evidence indicates #COVID19 has distinctive pathophysiological features that set the disease apart from respiratory failure of other origins.

A new 4-part Series in @LancetRespirMed explores COVID-19: Pathophysiology of Acute Disease: hubs.li/H0NyR540 .@osuchm et al. provide a comprehensive Review of the pathophysiology and phenotypes of #COVID19. Read in @LancetRespirMed: hubs.li/H0NySMY0.

Cardiovascular disease is responsible for 35% of deaths in women yearly—yet remains:
❣️Understudied
❣️Under-recognised
❣️Underdiagnosed
❣️Undertreated

NEW @TheLancet Commission outlines 10 recommendations to improve health outcomes for millions of women: hubs.li/H0Ns28Y0 275 million women were diagnosed with cardiovascular disease (CVD) in 2019. Acknowledging sex and gender-specific risk factors is the key to understanding #CVD in women and reducing the 🌍 burden.

Read the #LancetWomenCVD Commission: hubs.li/H0Ns28Y0

Migraine affects over 1 billion people worldwide, is the 2nd leading cause of disability, and a major source of losses to the 🌍 economy—yet professional and political awareness is lacking. Read a new @TheLancet Series on #Migraine by @MessoudAshina et al. hubs.li/H0J-73-0 In 2011, migraine cost Europe an estimated €50-€111 billion. Evidence suggests primary care could meet the needs of most #migraine patients, where available. Read an overview of migraine epidemiology, global burden, and migraine care challenges. hubs.li/H0J-73-0

63 million lives have been saved since 2000 by global efforts to #EndTB—efforts at risk from #COVID19. Achieving @WHO's #EndTB Strategy targets requires urgent action and investment.

On #WorldTBDay, access related content from across The Lancet titles 👇 Every day, nearly 4000 people die from #tuberculosis. Although considered a public health emergency for over 25 years, only modest progress has been made.

On #WorldTBDay, explore how recent advances could revolutionise #TB control & care in this Seminar: hubs.ly/H0JPlsv0