Thread by @KroganLab

In collaboration with @ZoicLabs, we produced an interactive rendition of our #SARSCoV2 Protein Interaction Map to facilitate the exploration of our dataset. Explore host targets, corresponding drugs/compounds, and other pathogen interactions. Link: ppi.zoiclabs.io/#/

This interactive map corresponds to our paper published today @nature (nature.com/articles/s4158…). The map contains clickable nodes to explore the known functions of #SARSCoV2 viral proteins and host targets, including host protein complexes and biological processes.

DRUGS/COMPOUNDS: Find detailed information about the drugs/compounds we identified to target #SARSCoV2 host factors (orange nodes). Many of these have potential to treat #COVID19 (see publication!)

OTHER PATHOGENS: We (@KroganLab and colleagues) have spent years cataloguing host-pathogen interactions. In this map, explore other pathogen proteins also known to interact with #SARSCoV2 host targets (red border), highlighting host proteins recurrently exploited by microbes.

STRUCTURES: Explore with ease known PDB structures for #SARSCoV2 viral proteins, which we hope will facilitate structural studies.

Use the filter function to easily search for your favorite protein, pathogen, drug, or PDB structure.

You can also find this map linked on our website at kroganlab.ucsf.edu/network-maps. We hope you enjoy it!