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Origin story of the HCQ PEP trial.

I have learned a ton from working with @boulware_dr and @DrToddLee and team on this trial.

Most important lesson:

Don’t let the details (like funding for example) get in the way of doing something important.
This trial was run on a shoe-string using innovative internet-based recruitment and follow up with centralized depot and administration
A reminder of how the 🇺🇸🇨🇦 HCQ PEP trial came to be through #IDTwitter.

We didn’t have any details of how or if this would work... Todd just decided to get it done, adapting David’s protocol to Canada with support from colleagues in Manitoba & Alberta.

All of this took place in the matter of a few weeks. No funding had been secured, authorship was not discussed... just a consensus that this was an important question to answer & it may as well be us (med.umn.edu/news-events/co…)
At around the same time that the plan was taking form, President Trump decided to get behind hydroxychloroquine for prevention and treatment of COVID19.
Over the course of the next weeks, hydroxychloroquine teetered between being hailed in the media as a miracle drug and a poison pill. This ultimately hamstrung our ability to recruit, particularly in the US

Fortunately with the event rate that was slightly higher than expected (in both arms) and loss to follow up lower, so we were able to reach close enough to target sample size to answer the question

Ultimately today’s publication is the culmination of hard work and strong leadership from @boulware_dr, @DrToddLee and a dedicated and talented team
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Keep Current with Ilan Schwartz MD PhD

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