nature.com/articles/s4158…
Here’s a #tweetorial to explain our #LesionSegregation findings...
[1/13]
- Mutagens generate lesions on each DNA strand, and segregate during replication
- Daughter cells have non-overlapping lesions, which are then resolved into full mutations
- Lineages with drivers undergo clonal expansion
[5/13]
![](https://pbs.twimg.com/media/EbSYClMWAAA9UKj.png)
[6/13]
![](https://pbs.twimg.com/media/EbSYI84XsAImxD_.jpg)
[7/13]
![](https://pbs.twimg.com/media/EbSYPJ8XsAAQH_y.jpg)
[8/13]
![](https://pbs.twimg.com/media/EbSYT0sWAAAmK97.png)
[9/13]
![](https://pbs.twimg.com/media/EbSYZYUXYAAZiVo.png)
🇬🇧🇪🇸🇮🇳🇩🇪🇪🇪🇬🇷🇳🇱🇮🇪🇱🇻🇺🇸
[10/13]
![](https://pbs.twimg.com/media/EbSZR5MWAAEF0_H.jpg)
[11/13]
And, of course, generous funding from @CR_UK, @ERC_Research, @wellcometrust, @EMBL, @The_MRC, @IRBBarcelona, @NIHRresearch.
[12/13]