A new mechanism of toxicity in Alzheimer's disease
revealed by the 3D structure of Aβ protein assemblies out in @NatureComms.
Researchers identify specific ensembles with the capacity to disrupt the membrane of neurons, causing their death.
➡️bit.ly/3i32Ilr
#IRBScience
revealed by the 3D structure of Aβ protein assemblies out in @NatureComms.
Researchers identify specific ensembles with the capacity to disrupt the membrane of neurons, causing their death.
➡️bit.ly/3i32Ilr
#IRBScience
“Knowing the features that characterise these protein ensembles (...) is crucial to design effective therapeutic strategies that target the forms of Aβ ensembles responsible for the neurotoxicity in Alzheimer's disease,” explains Natalia Carulla, who led the study.
“Our study suggests that some Aβ associations can perforate the membrane of neurons, alter their osmotic equilibrium, and consequently trigger their death,” say Sonia Ciudad and @Eduard_puig, first authors of the paper.
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