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Just out @nature: 35% of healthy people (#SARSCoV2 seronegative) have reactive SARSCoV2 CD4 T cells to spike protein, presumably d/t cross-reactive coronavirus exposure
nature.com/articles/s4158…
Important implications for explaining variable response to infections & vaccine trials
The healthy people in this report were an average age of 42, youngest age 20. Wondering what per cent in kids with ready made CD4 T cells vs #SARSCoV2 (likely higher than 35%)
The healthy people SARSCoV2 seronegative and their T cell reactive response (RHD) to the 4 common cold coronaviruses
(from supplementary material).
Extends prior work @CellCellPress cell.com/cell/pdf/S0092…
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