Why #psychiatry research seems to exist in a parallel universe: "Academic psychiatrists who pursue research careers may not have patients after residency, let alone practice psychotherapy." -- psychologist Jonathan Shedler psychiatrictimes.com/view/psychoana…
"But aren’t we seeing the same kind of arrogance & reductionism in #psychiatry today?....I cannot tell you how many depressed patients I’ve worked with...successfully....who had been on 1 medication after another for years or decades with little benefit." psychiatrictimes.com/view/psychoana…
"These patients often go from #antidepressants to mood stabilizers to atypicals....We see polypharmacy nightmares, with patients on 5 or 6 or more #psychiatric medications, and they are just as depressed as when they started." psychiatrictimes.com/view/psychoana…
Awais Aftab: "The poor long-term efficacy outcomes of status quo treatments for depression, whether these are #antidepressant medications or manualized therapies, are well-recognized within the [mental health] profession but rarely advertised." psychiatrictimes.com/view/psychoana…
Awais Aftab: "The uncomfortable truth is that majority of patients with depression (and other disorders, such as PTSD, anxiety, etc.) do not experience sustained recovery with either medications or short-term manualized therapies" (which are often CBT). psychiatrictimes.com/view/psychoana…
Jonathan Shedler: "latest state-of-the-art network meta-analysis for #antidepressants [Cipriani, 2019] reported an effect size of d = .30....translates into 1.7 points on the Hamilton Depression Rating Scale (HDRS)—which is obviously clinically trivial." psychiatrictimes.com/view/reducing-…
Dr. Shedler: "Before people start sending hate mail....#Antidepressants work well for some depressed patients some of the time. But “research shows” they do little for the average patient with major depression in research trials, even in the short run." psychiatrictimes.com/view/reducing-…
• • •
Missing some Tweet in this thread? You can try to
force a refresh
FACT: “Chemical imbalance” or "neurotransmitter deficiency theory" was deployed by pharmaceutical companies to advertise their #psychiatric psychotropics. Never been scientifically proven, debunked many years ago, still circulating as rumor 20+ years later.
See sources below. /1
@_pem_pem Why this is nonsensical: "Jeffrey Lieberman, a professor of #psychiatry at Columbia University...“The problems that they’ve been criticized for have more to do [with] the way they’re used by doctors & the heterogeneity of the condition that they’re indicated for.” /1
@_pem_pem What Lieberman is saying is that if #antidepressants were prescribed to a population for which they are known to work well, they would have a much better track record. This is true, because it is a tautology. /2
@_pem_pem The reasoning is circular, if #antidepressants were prescribed for those people for whom the drugs worked, they would work. /3
Monoamine hypothesis aka "chemical imbalance" & other synonyms, arose circa 1965, but was known to only #psychiatrists, who were unhappily prescribing TCAs and MAOIs to a niche market. Patients hated the many adverse effects of the drugs. /1
Until mid-1990s, monoamine hypothesis (aka "chemical imbalance", "serotonin deficiency" etc.) was not circulating as a "folk model", not in medicine or in the general public. 1990 is ~center of this chart, when #psychiatrists, many paid by pharma, started churning out papers. /2
As a meme or "folk model", monoamine hypothesis (aka "chemical imbalance", "serotonin deficiency", "neurohormone imbalance", etc.) was diligently planted by dozens of #psychiatrists -- not a few -- many paid by pharma. Not something that arose organically out of nowhere. /3
Lewis, et al. respond to letters to the NEJM editor, demonstrating they do not understand basic concepts of #antidepressant withdrawal @ANTLERtrial
Maintenance or Discontinuation of Antidepressants in Primary Care | NEJM nejm.org/doi/full/10.10…
@ANTLERtrial Some in non-discontinuation group were taking their drugs inconsistently. Lewis, et al. missed potential withdrawal symptoms in that group: "but participants reported some new & worsening symptoms while continuing to take #antidepressants"
@ANTLERtrial Lewis, et al. claim "an increase in depressive symptoms might lead to an increase in “new & worsening” symptoms that are recorded as withdrawal symptoms" EXCEPT they also recorded physical withdrawal symptoms, failed to identify who had both, & did not exclude them from "relapse"
@sanilrege@markhoro@SenadHasanagic1 Not at all, Sanil. Among my site members, many people come off #antidepressants & other drugs with slight or no withdrawal symptoms except an emotional anesthesia, which they may describe as depression, anhedonia, various kinds of malaise, even "relapse" but.... /1
@sanilrege@markhoro@SenadHasanagic1 ....it's a "relapse" unlike anything they've experienced before. While they may use #psychiatry's vocabulary, because that's all they've got, this emotional anesthesia is actually a result of long-term psychotropic exposure, not "relapse"..../2
@sanilrege@markhoro@SenadHasanagic1 Post-drug emotional anesthesia is well known among those who have gone off psychotropics classified as addictive & considered a feature of those protracted withdrawal syndromes. There is no reason to think chronic #psychiatric psychotropics are exempt..../3
With all due respect to the fine @awaisaftab, these are the varieties of #antidepressant withdrawal syndrome:
1) WS with only physical, no emotional symptoms 2) WS with both physical & emotional symptoms 3) WS with only emotional symptoms 4) WS manifested as emotional anesthesia
@awaisaftab Of the above, types 1 & 2 are WS, not "relapse", even if "depression" is present. Emotions such as those that compose "depression" do not exist apart from experience. Emotional reaction to feeling neurobiologically out of control should not be diagnosed as "depression".
@awaisaftab Type 3 may include the waves of intense anxiety, fear, & "black holes" characteristic of WS. Characterized by intense sensations with interludes of relative calm. Typically, these very gradually abate over months.