(1) Hamster Study shows #D614G mutation vastly increases the coronavirus virulence in both nasal mucosa and lung tissue.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
(2) Four sets of Hamsters were infected with either mock virus, D614 variant, G614 variant and a 50/50 mix of both variants of the coronavirus.
Hamsters harvested for tissue analysis on day 2, 4, and 7 of a 7 day study.
Hamsters harvested for tissue analysis on day 2, 4, and 7 of a 7 day study.
(3) Trachea, Lung Sections and Nasal Wash were collected and analyzed to measure the concentration of the two variants.
Once again, animals gave their lives to help us live. Bless them.
Once again, animals gave their lives to help us live. Bless them.
(4) By day 4 for the 50/50 mix group, the G614 variant was more than an order of magnitude more successful at replicative fitness.
This variant first hit Europe and then New York City.
This variant first hit Europe and then New York City.
(5) Earlier this year, researchers at @LosAlamosNatLab had suggested the D614G mutation could explain the more rapid spread seen in Italy, Spain, Belgium, the UK and NYC, with G614 being dominant at these locations, while D614 was dominant in Wuhan.
(6) During outbreaks in Europe and North America, different locations had different relative amounts of the two variants.
The G614 variant correlated with faster rates of transmission.
The G614 variant correlated with faster rates of transmission.
(7) The new study also showed that D614G substitution improves SARS-CoV-2 replication on Human lung cealls (Calu-3) through 574 increased virion infectivity.
(7) The new study also showed that D614G substitution improves SARS-CoV-2 replication on Human lung cells (Calu-3) through 574 increased virion infectivity.
(8) While animal model testing results in the killing of many sentient animals, they have been key building blocks in the investigation of SARS-COV-2.
Another Hamster study showed the efficacy of surgical mask fabric at preventing airborne infection.
Another Hamster study showed the efficacy of surgical mask fabric at preventing airborne infection.
(9) A SARS-COV-2 Ferret study also demonstrated airborne transmission, though the church of medical orthodoxy has been reluctant to admit their March recommendations about droplet transmission being the primary vector were wrong.
Six feet are not enough.
Six feet are not enough.
(9) Countless animal studies have been instrumental in the rapid advancement of vaccine candidates to the human trail stage.
While some of us are outraged about the inhumane treatment of animals, we can agree to solemnly remember their contributions to medical science.
While some of us are outraged about the inhumane treatment of animals, we can agree to solemnly remember their contributions to medical science.
(10) Credits and References:
@LosAlamosNatLab
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biorxiv.org/content/10.110…
@LosAlamosNatLab
@threadreaderapp unroll
biorxiv.org/content/10.110…
