Discover and read the best of Twitter Threads about #d614g

Most recents (14)

Variant that could potentially affect more people who are vaccinated against COVID-19.
#Vaccine creates #variants

#Nsp12 #W152L #C241U Mutations

Also found in all VOCs #P323L and #D614G mutations.

"What Is the R.1 COVID-19 Variant? What We Know So Far" health.com/condition/infe…
Orf9c
N proteins
Read 5 tweets
Ergänzend zum gestrigen #OktoberImAugust Thread heute noch ein paar weitere Einblicke in #Hospitalisierungen #Kinderdurchseuchung
TLR: #KeineEntkopplung:
Steigt Inzidenz, steigt #Belastung der Krankenhäuser - und der niedergelassenen sowieso.
Ausführlicher im Thread:➡️
1/x
2/
Betrachtet man die #Hospitalisierungsinzidenz-en für alle Altersgruppen über den Gesamtzeitraum, sieht erstmal alles #Tutti aus, weniger als KW44/20 bis 23/21.
Aber zu den Werten gehörten auch 90.000 Tote, das wollen wir ja auch nicht wiederholen.
Wie ist der Trend?
➡️
3/
Betrachtet man letzte 2 Monate, steigt nicht nur #Hospitalisierung bei #Kinderdurchseuchung, sondern auch bei 80+ sehr deutlich,
ebenfalls 60-79Jahre steigend, ähnliche Höhe wie #Hospitalisierungsinzidenz der 0-4Jährigen.
War das zu erwarten?➡️
Read 48 tweets
#Spike protein’ is the major target of #NAbs in infected/vaccinated people. The prefusion conformation of the Spike represents the most relevant target because Abs can successfully interfere w/ infection only if they prevent binding to target cells or prevent fusion itself 1/
Various approaches are adopted to express ‘#Spike’ protein in vivo, such as nucleic acid structures & virus vectors. Alternatively, other vaccine platforms like recombinant protein particles & inactivated vaccines can directly deliver this protein 2/
Most structural studies of the wild-type spike protein exhibited one #RBD in the 'open' conformation. By contrast, 2 or 3 RBDs were observed in the open conformation in the more infective #D614G mutant--the RBD #conformation plays a vital role in the infectivity of SARSCoV2 3/
Read 16 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Is there any role of large-scale vaccination in containing the ongoing surge in #India? The current estimate of herd immunity threshold is around 60%-70% based on the estimate with old variant #D614G. 1/
With the advent of new, more transmissible #variants, the estimate for a herd immunity threshold may further go up. The pace of inoculation is very sluggish, inoculated a meagre 2.0 % of our population with 2 doses! May take few years to reach anywhere near the threshold 2/
We are currently on the ascending limb of an outbreak propelled by a highly transmissible virus with a high reproduction number (Ro). Further, there is confusion over what it means to reach herd immunity 3/
Read 15 tweets
This tweet thread is about the #Covid_19: Updates from Singapore webinar on 26 Feb 2021

I've been busy so this is ~ a month after

It will be followed by a tweet thread documenting a more recent episode that was last week
#Covid_19 : Updates from Singapore is a webinar organised by @WHOGOARN and @NUSMedicine

And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
We are joined tonight by Dr. Peter Karim Ben Embarek
Read 51 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
Mucho se habla sobre las #variantes del SARS-CoV2. @EricTopol cita aqui como antecedente la "altamente adaptada" #D614G, mejor estudiada que las más recientes (UK, SA y Brasil), Precisamente esa mutación nos va a servir para poner algo de perspectiva. Abro hilo 🧵 1/21
El siguiente tuit del mini-hilo de @EricTopol cita un trabajo muy interesante que trata de esclarecer el significado de esa mutación D614G
El trabajo concretamente es este 👇
nejm.org/doi/full/10.10… 2/21
El trabajo, publicado en el muy prestigioso @NEJM se titula "Emergence of a Highly Fit SARS-CoV-2 Variant" y se refiere a la mutación D614G. Recordemos: esa mutación fue identificada en febrero en el sur de Europa y se extendió sustituyendo a las precedentes. 3/21
Read 22 tweets
(1) Hamster Study shows #D614G mutation vastly increases the coronavirus virulence in both nasal mucosa and lung tissue.

biorxiv.org/content/10.110…
(2) Four sets of Hamsters were infected with either mock virus, D614 variant, G614 variant and a 50/50 mix of both variants of the coronavirus.

Hamsters harvested for tissue analysis on day 2, 4, and 7 of a 7 day study.
(3) Trachea, Lung Sections and Nasal Wash were collected and analyzed to measure the concentration of the two variants.

Once again, animals gave their lives to help us live. Bless them.
Read 12 tweets
(1) What can we learn from the Japanese Model?
(2) Japan did not order a lockdown. Instead they wore high quality surgical masks (ASTM-F2100 prefered), and THEY COMPLIED.

China and Hong Kong also complied.
(3) On a per capita basis, the difference between the United States' outcome and Japan's couldn't be more stark.

I had to plot it with semilog axes just to get both curves on the same graph!

This is possible, if we act together, and COMPLY.
Read 11 tweets
(1) Could #COVID19 mutant #D614G the variation seen in Transmission Rates (Rt's) and Case Fatality Rates (CFR's) between locations?

biorxiv.org/content/10.110…

#BreakingNews #coronavirus
(2) A group of researchers prepublished their findings about the #D614G mutation to the SARS-Cov-2 affecting the properties of the Spike protein that binds to host cell sites.
(3) The paper includes a diagram showing the emergence of the #D614G mutant and its descendants, first in Belgium, and later in hot spots in Europe and the United States.

The relative quantities of the this mutant strain could explain the variations seen in Case Fatality Rates!
Read 28 tweets
🚨US scientists say a new #coronavirus strain emerged in March and now dominates worldwide. The mutant (spike protein #D614G) appears to be *more contagious* than versions that spread early in the #CoronavirusPandemic and may bypass immunity to 1st strain.
latimes.com/california/sto…
Wherever the new #coronavirus strain appeared, it quickly infected far more people than earlier strains from #Wuhan, and within weeks it was the ONLY strain dominant in some nations. The new strain’s dominance demonstrates that it is more infectious, but it's not yet known why.😳
Prior scientific reports did NOT reveal any significant mutations that affected the infectivity of the #coronavirus. This new report is very troubling, as it may mean that immunity to the 1st strain or vaccines directed against the 1st strain may NOT be effective against the 2nd.
Read 5 tweets

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