1/n Continuing the discussion of the #bradykinin hypothesis, from the old thread ()
2/n You'll have to be a real multiplex cycle geek to like the next couple of tweets, but I'll get back to keeping it simple after those next tweets.
From Figure 2 of the paper, elifesciences.org/articles/59177, when the renin–angiotensin system (RAS) system goes wonky, it gets complex
From Figure 2 of the paper, elifesciences.org/articles/59177, when the renin–angiotensin system (RAS) system goes wonky, it gets complex
3/n Click on the pix to enlarge; read the paper. The aim of these overly geeky tweets is to be able to explain soon the important bits simply. The below is just an aid to understanding the above.
4/ FINALLY we get to the important, easy bits. All the foregoing was for y'all to be able to refer back to bits & pieces in the grand scheme of things.
From the Medium report: elemental.medium.com/a-supercompute…
Some cardiac effects from #COVID19 as side-effects of (acute) #BradykininStorm
From the Medium report: elemental.medium.com/a-supercompute…
Some cardiac effects from #COVID19 as side-effects of (acute) #BradykininStorm
5/ Now we get to educating me. I always tend to simplistically think in terms of the brain of bloodvessel stoppage (thrombosis) or full-scale blow-out (brainbleed), but it's. not. that. simple..
From the Medium report: #bradykininstorm causing leaky blood vessels
From the Medium report: #bradykininstorm causing leaky blood vessels
6/n So, possible in severe #COVID19, lots of tiny little brainbleeds, would be how my tiny brain simplistically sees it. From the Medium post, #BradykininStorm also doing (maybe) #COVIDtoes (acro-ischemic lesions).
cc. @evolutionarypsy
cc. @evolutionarypsy
7/n From the paper: so the various effects of a #BradykininStorm, in various places in the body, including the grim bit about forming hydrogels in the lungs, reducing oxygen access.
8/n From the paper, that bit in more detail if you like. Yes, Vitamin D makes an entry, don't flame me, bro, but it's still not a wonder-cure, it only helps a bit, don't even spam me. Note the associated hypokalemia.
9/9 New thread:
