This is my last week at @sloan_kettering after 8 1/2 years. No one had as much impact as @rosslevinemd, and so with my final MSK tweetorial before @cohesinlab moves to @columbiacancer to start @cohesinlab, a few of my favorite memories and pearls of wisdom from @rosslevinemd 1/25
In 2016 during the Vice President’s @CancerMoonshot initiative, there was a planned visit for @JoeBiden to come to @sloan_kettering. I heard the original plan was to visit the @CharlesSawyers lab, but Secret Service preferred the RRL building. 2/25
@rosslevinemd met and spoke with VP @JoeBiden then led him through each laboratory bay where a handful of us were waiting to tell him about our work with a “cooking-show” style setup ready. My station was a western blot (an old, super unsexy protein quantification assay). 3/25
It led to an amazing photo op as we looked at x-ray film held up to the light as Ross looked on proudly. @JoeBiden listened intently, asked thoughtful questions, then moved to the next bay. We went home inspired to redouble our efforts to improve the lives of cancer patients 4/
Ross is very active with @Cycle4Survival, an amazing organization raising money for rare cancer research @sloan_kettering. Ross and I both often speak at events, which are so moving, and we have become very friendly with the amazing development team headed up by Katie Klein. 5/
Katie emailed Ross sometime in 2017 asking for a pair of hospital scrubs. He passed the request to me and I left a pair on my desk for Katie to pick up. A month later my sister @arielleviny, a photo producer in LA, calls asking why she has my scrubs and white coat in her mailbox
It turned out my very used very dirty scrubs from residency were not so much “borrowed” but rather cut and redesigned by @virgilabloh @OffWht into a tracksuit which sold at auction, raising $5500 for @Cycle4Survival. And a video...7/25
Ross recently won the @ASH_hematology Dameshek prize at the 2018 Annual meeting. It is a huge honor bestowed upon an investigator under age 50 who has made a significant contribution to the field. Commensurate with this honor we threw Ross-a-palooza. 8/25
Hosted at a great outdoor venue with an open bar, DJ’ed by @mdmcmax, and 500 temporary tattoos of Ross’s face (my wife Aly’s idea). Former trainees, colleagues, and friends came out to celebrate Ross (and wear a tattoo of his face on their body)—a true testament of his character
Those that know Ross also know he is a teeny tiny bit competitive 🤪 Well, to celebrate the 10th anniversary of @rosslevinelab, he took current and former members to @Woodloch for a retreat with science, relaxation, and outdoor activities. 10/25
We bribed an @ASH_hematology admin to get the “ASH team” football jersey she wore at the year prior’s presidential reception on the field at @GeorgiaDome and that jersey is now framed in his office, signed by every trainee. 11/25
As a final activity we had a scavenger hunt. 3 teams, puzzles, games, physical feats. Wouldn’t ya know it, but Ross’s team won, earning woodloch medals. To this day, he will walk into the lab, his medal proudly around his neck anytime he feels he needs to reassert his dominance!
Ross was recently promoted to chief of molecular cancer medicine @mskcc and to celebrate him, knowing how big of a @Mets fan he is, we got a @cameo video from @BobbyValentine. 13/25 cameo.com/v/L8jOAj1nL
Better still, a great friend to the lab and giant in the field, @leonard_zon made his own video! 14/25 dropbox.com/s/xdlv2d28p2l8…
Last summer Ross and I met in his office to discuss whether it was the right time to start my job search. We planned, we strategized, and after giving a talk at @FASEBorg Hematology the job search had officially begun. 15/25
We talked through scope and focus of my future lab, he edited research statements, practiced chalk talks. Behind the scenes, he emailed and called key contacts. I interviewed across the country meeting scientists whom I greatly admire as I “ran the plays” Ross drew up. 16/25
Then COVID hit. Hiring freezes took 2/3 of the programs I had looked at from being options (tweeted in detail previously). Unsolicited, Ross reached out to the programs I was most interested in to offer his financial and laboratory resources to me for any transition period. 17/
The COVID pandemic was the most physically and emotionally taxing clinical medicine I have ever experienced (tweeted in detail previously). I would not have gotten through it without @rosslevinemd. 18/25
I confided in him that just before starting on service that Aly and I had just found out we were pregnant after a long time trying. He also knew my fears as a BMT survivor in getting COVID conflicted with my sense of duty to my colleagues and my patients. 19/25
He knew the best way to help was to ensure I knew he had my back (and he did). We communicate often by email, or slack, or text, but during COVID he called by FacetTime once if not twice daily. He was called to talk, yes, but he was also doing a realtime physical exam. 20/25
When I tell people interested in joining @rosslevinelab that Ross really and genuinely CARES, this is what I mean. The guy cares about his trainees as scientists and he cares about his trainees as complete humans. 21/25
My time as a member of the @rosslevinelab has been some of the best years of my life, spent with some of the most phenomenal, fearless, and innovative scientists around @bowman_rl @RichardKoche @lindemilesphd @shengfcai @Lindsay_LaFave @AbdelWahablab @gur_ola @Britt_icisms 22/25
@PedsHemeDoc @ElodiePronier Andy Dunbar, Alan Shih, Priya Koppikar, Neha Bhagwat, Michael Waarts, Aaron Stonestrom, Pablo Sanchez Vela, Troy, and Ines. 23/25
If you are a high school/college student, apply to summer programs in @rosslevinelab
If you are a college graduate, apply to be a technician in @rosslevinelab
If you are a medical student, apply for the @ASH_hematology HONORS program to spend a year in @rosslevinelab 24/25
If you are a fellow, talk to @rosslevinemd about joining the @rosslevinelab or at least make @rosslevinemd
If you are a PI, schedule a joint lab meeting with the @rosslevinelab
His enthusiasm is infectious, his mentorship inspiring. You won’t regret it. 25/25

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More from @TheDoctorIsVin

29 Jul
The Viny lab @cohesinlab is looking for motivated and courageous postdoctoral scientists to join our small but mighty group. @cohesinlab will open next month at @ColumbiaMed @columbiacancer & @CSCIColumbia (1/15)
We will focus on employing new and existing mouse models, primary patient samples, and state-of-the-art epigenomic/transcriptional assays for assessing 3-dimensional chromatin structure in the malignant context. These are the core principles by which we will operate: (2/15)
1. We are and will always be focused on improving the lives of the patients afflicted with cancer. Yes, we will work hard to secure grants and papers but those are simply the means to achieve our primary mission (3/15)
Read 15 tweets
1 Jul
1/ Sometimes coincidence makes you take a beat. Today is day +6,209 (17 years) since my allogeneic bone marrow transplant for relapsed Acute Lymphoblastic Leukemia. Today I am rounding as the inpatient leukemia attending. I brought cake.
2/ And I’ve tweeted my annual transplant anniversary before—worthy of much celebration—but this year is different. Even different from my 10 years cancer free as a @sloan_kettering fellow on the BMT service.
3/ Because this year, while I celebrate on service, it’s also my last week as an attending physician at MSK.
Read 17 tweets
12 Apr
1/n Today is day 28 away from wife and daughter. The first half of this separation was spent as leukemia attending @sloan_kettering for both #COVID19 and non-COVID hospitalized patients before cohorting strategies began and while guidelines for stewardship of #PPE were in flux
2/ We continued to give world class care to our patients, but that meant high risk exposures to my team and myself. Friends and colleagues with cough or other concerning symptoms were sent immediately for testing thanks to the amazing laboratory medicine dept efforts by @EBabady
3/ Many healthcare workers were found to be positive and went home with a range of disease severity and symptomatology. One thing was clear--our exposure risks were just as much from each other as from the patients. #HeroesOfCovid19
Read 21 tweets
11 Feb
1/ A wonderful “state of the physician scientist” training overview of what programs are doing to support us along the continuum of medical education and training. Hard to break in unless starting in a dedicated program or with grant support.
2/ With T32/F31 @NIHgrants only available for MD/PhDs, the entry point for non-PhD MDs took a major hit with the ending of the @HHMINEWS HHMI Med Fellows program. For me this was a major accelerator.
3/ To get into a great MD/PhD program, now ~2 gap years in a lab is nearly a requirement, further increasing the age of trainees when completing residency, yet still needing additional “instructor” aka post-doc years. Financial/family struggles influence career pathways
Read 10 tweets
19 Mar 19
A #tweetorial from @RossLevineLab and colleagues on our new preprint online today at @biorxivpreprint from @sloan_kettering biorxiv.org/content/10.110…
1. The cohesin complex is comprised of structural proteins (Smc1a, Smc3, Rad21) bound to a Stag protein (most commonly Stag1 or Stag2). The entire complex is targeted by somatic mutations in myeloid malignancies, whereas STAG2 is most prevalent across all cancer @cohesin_papers
2. We & others have described that the core cohesin complex regulates hematopoietic self renewal & differentiation. However the fundamental biologic mechanism remained unclear & the unique role of Stag2 in gene regulation, hematopoiesis & transformation was not known.
Read 18 tweets

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