2/
An important point to start:
Distribution is LEAST important in the skin exam. Primary & secondary lesions, configuration & scale are all better in informing our DDx.
I tell my learners that if confused about a rash, pretend it's elsewhere on the body & see if that helps.
3/
Also - throughout this #tweetorial, I will try to display skin disease in lighter & darker skinned patients side by side. Remember in darker skin, erythema is harder to see, so I hope this highlights the point!
A question: In tweet 1, what distribution is shown in the photo:
4/
Answer: PHOTODISTRIBUTED!
The photos in tweet 1 are of polymorphous light eruption (PMLE), which is a reaction the skin can have to UV. With repeated exposure, things improve, so patients improve over the summer.
A sunburn 👇 is the best example of a photodistributed rash.
5/ Sometimes it's not so simple. In these pictures, we are seeing an effect from an ingested drug causing a phototoxic reaction (when it happens in the nails as we see in pic 2, it's called photoonycholysis).
Doxycycline is a common culprit for this. A good history is critical!
6/ The next we'll cover is the "opposite" to photodistributed: BATHING SUIT DISTRIBUTION (basically where the sun don't shine)!
The best example of this is mycosis fungoides, the most common type of cutaneous t-cell lymphoma.
8/ But realize that in kids, especially babies, we tend to see eczema all over. I was taught it had to do with the lack of scratching, but to be fair, really bad eczema in adults is also all over the place. I think adults are just worse at controlling scratching in milder cases.
9/
Next up - ACRAL DISTRIBUTION!
First, an ah-ha moment I had in residency to share: The word "acral" doesn't mean palms and soles. It actually means distal extremities, so the whole hand, whole foot, and even the ears are involved!
And NOT everything is syphilis, RMSF, or EM!
10/ While syphilis, RMSF, & erythema multiforme are great things to suspect, there are other things to consider, which I discuss in this tweetorial:
11/
Okay, next up, SEBORRHEIC. This one is unusual, but usually I think scalp, T-zone, by the nasal ala, periumbilical, under the breast, and in the groin (pic 1).
As you might expect, seborrheic dermatitis is a great example of something in this distribution (pic 2).
12/ Another eruption in the seborrheic distribution is quite rare. Darier disease is a genetic mutation in ATP2A2 (a calcium channel) which causes blistering in the skin in the seborrheic distribution (pic)! This is one of the rare genetic blistering diseases we see!
13/ Interestingly, a related genetic blistering disorder called Hailey Hailey (pic) will bring us to the next distribution: INTERTRIGINOUS! You see the macerated plaques that are often malodorous, starting in the skin folds!
14/ Otherwise, the most common thing in the skin fold would be intertrigo (pic1). Another pearl from residency: intertrigo is irritation from skin rubbing. It's not candida unless you see satellite pustules!
Note that some rashes can also be intertriginous, even psoriasis (pic2)
15/ Another intertriginous "rash" would be these sinus tracts and cysts, seen in hidradenitis suppurativa. This rash tends to occur with dissecting cellulitis, acne conglobata, and pilonidal cysts. Together, this is called the follicular occlusion tetrad (which is a misnomer...).
16/ Last one - CONTACT DERMATITIS DISTRIBUTIONS
Notice how in pic1, we see an axilla, but sparing of the innermost vault? This is good for a contact derm to clothing.
Whereas pic2 in a patient who is frequently washing their hands (aren't we all) might be contact derm to soaps.
17/ RECAP:
✅ In the world of morphology, distribution helps, but the other categories are more important.
✅ Certain distributions might warrant a good history (eg: contact derm or new meds)
✅ Acral is the whole hand & foot, & ears!
✅ I've made too many #tweetorials😳
18/ This wasn't an exhaustive list, but I just wanted to run through how distribution can be helpful with some common examples!
For you video-based learners, check out the video version I made of this #tweetorial!
Hope this was helpful!
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Hi #medtwitter and #dermtwitter! Since I'm giving a talk at the upcoming @SocietyHospMed Converge meeting, I thought I'd put together a brief #tweetorial on:
DIFFERENTIATING PEMPHIGUS AND PEMPHIGOID!
Follow along for a reminder on how to tell them apart! 1/
Reminder that Pemphigus is from an antibody targeting the Desmosome - which holds skin cells (keratinocytes) together.
Pemphigoid is from an antibody targeting the Hemidesmosome, which holds keratinocytes to the basement membrane.
pc: 2/ bookdown.org/jcog196013/BS2…
So to remember:
pemphiguS (S for Superficial/higher up)
pemphigoiD (D for Deep/lower down)
This also means the clinical exam is different. Since Pemphigoid is deeper, these bullae stand tall and proud and don't droop over (see pic)! We call these TENSE bullae. 3/
If everyone could just humor me for a little, here's a #dermtwitter/#medtwitter/#pharmtwitter #tweetorial on...
AZATHIOPRINE
Did you know that dermatologists use this medication too? Read on to see all the ins and outs of safety and dosing, from a #dermatology point of view! 1/
Did you notice those two rings above? That's how it works.
Azathioprine is a purine (see figure) analogue, so it gets in the way of RNA/DNA synthesis (making transcription and replication and all that downstream goodness more difficult). 2/
And as you might imagine, cells that are rapidly dividing (like your immune cells) would be affected more by this purine disruption.
But it's not azathioprine itself that does all the work. It has to be broken down into active metabolites and that's where it gets interesting. 3/
The spirochete Borrelia burgdorferi is the most common cause. It is transmitted via tick bite, and so, certain areas of the country have higher rates based on endemicity of the organism.
What tick classically transmits lyme?
2/
Ixodes tick is the classic vector for B burgdorferi. But remember:
The tick usually has to be attached to the patient for >36 hours to transmit and cause Lyme disease.
Can you identify all these types of ticks and pick out which one is Ixodes?
We're seeing more consult questions for this, and it's also garnering national attention, so let's take a brief moment in #tweetorial format to talk about:
What is Xylazine? It was created in the 70s as a veterinary anesthetic. As an analog of clonidine, it has similar effects as an alpha-2 agonist, leading to sedation, anesthesia, and euphoria in the CNS. 2/
Recently, Xylazine has entered the drug supply, moreso in certain cities, but increasingly everywhere. It is often mixed with fentanyl as a cutting agent, and can also be used on its own. It may be called Tranq, Zombie Drug, or anestesia de caballo (horse anesthetic).
3/
Let's go back to the basics. Syphilis is from an infection by the bacterium Treponema pallidum. Usually spread by sexual means, syphilis has three main stages of disease.
Primary infection usually presents as a papule that turns into a painless ulcer called a chancre. 2/
Time from inoculation to chancre usually is 10-90 days (21 days is most typical).
There is a rare variant where the patient can get many smaller ulcerations, which is called Follman balanitis. 3/
Let’s spend some time in this #tweetorial on the dermatologic manifestations of this potentially paraneoplastic disease!
First, a question: What is necessary to make a diagnosis of DM?
1/
None of the above! DM is a clinical diagnosis, which is why getting the exam right is super important! That said a biopsy CAN help with getting to a diagnosis, but it’s not necessary.
So let’s start! Heliotrope rash! This poikilodermatous erythema occurs around the eyes. 2/
Remember though that exams are different across skin tone. Heliotrope can look a lot more subtle in someone with more melanated skin. That rash can also include the rest of the face! 3/