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IRB Barcelona Profile picture
@IRBBarcelona
Sep 22, 2020 • 4 tweets • 3 min read • Read on X
#IRBScience: Published in @GenomeMedicine, the latest work from the SBNB lab points to the co-occurrence of #cancer driver genes as a key to precision medicine.

Read👓the news➡️bit.ly/2RP3WFf

(1/4) Follow this thread to learn more ↘️
#WorldCancerResearchDay
The system is called Targeted Cancer Therapy for You (TCT4U), and it's aimed at predicting tumour response to different treatments.💊

It has allowed the identification of a set of complex biomarkers🧬that have now been made available to the medical-scientific community.

(2/4)↘️
"The sum of two or more mutated #Cancer driver genes affects the tumour's response to treatments" says @ptck72, "through this work, we see that studying cancer driver genes as a whole can bring about a great advance towards precision medicine".

#WorldCancerResearchDay
(3/4)↘️
"We were able to predict the outcome of the therapy in 12 of the 14 case studies, well above the power of approved biomarkers to predict drug response," explains first author #LidiaMateo.

Read👓the news➡️bit.ly/2RP3WFf

and (4/4).

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More from @IRBBarcelona

IRB Barcelona Profile picture
Apr 25, 2022
🔬An international consortium, led by #IRBBarcelona & the biotech company @MerusNV, reports the discovery of MCLA-158, the first clinical candidate screened in #organoids targeting 🎯 #cancer #stemcells of solid tumors.

📰@NatureCancer

➡️bit.ly/3MLiu3h

#IRBScience Image
Named Petosemtamab, the antibody MCLA-158 prevents the onset of #metastasis (that is, the spread of #cancer to other vital organs) and slows the growth of primary tumours in experimental models of cancer. Image
The study also lays the groundwork for the use of #organoids in the #DrugDiscovery process undertaken by pharmaceutical companies.

Organoids are patient-derived samples that can be grown in the laboratory, and they reproduce certain aspects of the tumour compartment. Image
Read 6 tweets
IRB Barcelona Profile picture
Sep 21, 2020
Today is #WorldAlzheimersDay 🧠 and this disease has been on #IRBBarcelona's agenda since its start.

@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)
In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.

➡️bit.ly/3clhW34
#IRBScience #WorldAlzheimersDay
(2/4)
In fact, the @ShorterLab, one of the 🔝groups in protein aggregation, published a review on their work in @TrendsNeuro.

➡️cell.com/trends/neurosc…
#WorldAlzheimersDay
(3/4)
Read 4 tweets
IRB Barcelona Profile picture
Sep 7, 2020
The Evomet project, coordinated by #IRBBarcelona, will train future leaders in metastasis research.

Read the news➡️bit.ly/324VEid

Follow this thread to meet the labs participating⬇️
(1/9)
At @IRBBarcelona, the Growth Control and Cancer Metastasis lab, led by @RogerGom1, will be hosting two students.
irbbarcelona.org/en/research/gr…

@MarionaGraupera will also mentor two students in the Vascular Signaling Lab, which she leads at @idibell_cat. procure-ico.eu/mariona-graupe…
(2/9)
At @IMPvienna, @obenaufa will be training one of the future leaders in metastasis research, in the Obenauf lab obenauflab.com

A position is available alongside @ClareIsacke, Head of the Molecular Cell Biology team at @ICR_London.
icr.ac.uk/our-research/r…
(3/9)
Read 9 tweets
IRB Barcelona Profile picture
Sep 4, 2020
@IRBBarcelona coordinates the European Project Evomet to train 15 young scientists and future leaders in metastasis research with the aim to identify therapeutic solutions. The project has received €4 M and will last for four years.

irbbarcelona.org/en/news/irb-ba…
At Evomet also participate: @idibell_cat idibell_cat @imperialcollege @BreastCancerNow @idibaps @unil
@Cambridge_Uni @GustaveRoussy @ULBruxelles
@UniBasel_en @Boehringer @intomics @ChromaCure
Each of the institutions will host one of the selected young researchers and will train them until they complete their doctorate, except for @IRBBarcelona and @idibell_cat IDIBELL, which will host two predoctoral researchers each.
Read 4 tweets
IRB Barcelona Profile picture
Aug 17, 2020
#IRBScience: The @bbglab publishes "A compendium of mutational cancer driver genes" in @NatureRevCancer, with mportant implications in clinical decision making.

📢568 genes identified with the potential to trigger #cancer!

➡️bit.ly/2DUxvSn
(1/5) @nlbigas @fran_mj88
The study stands on the analysis of the genomes of 28,000 tumours from 66 types of cancer and it's a major update of the #IntOGen platform (intogen.org), aimed at identifying mutational cancer driver genes.

(2/5)
“The compendium of driver genes provides cancer researchers, both in the clinical and basic research setting, with crucial knowledge and it has an important impact on clinical decision-making,” says @nlbigas, head of the @bbglab at @IRBBarcelona and @icreacommunity.

(3/5)
Read 5 tweets
IRB Barcelona Profile picture
Aug 5, 2020
📢TLK protein inhibition activates the innate #ImmuneSystem, thus becoming a potential therapeutic target for enhancing the effect of some #cancer treatments.

The latest study from @genstability lab is now out in @CellReports.

➡️bit.ly/2PoObDR
#IRBScience
(1/2) Image
“The activation of innate immunity in cancer has recently become an active area of ​​research as it has become clear that the innate immune response influences chemotherapy and immunotherapy,” comments @genstability, who recently took up a new position at @theNCI.
(2/4) Image
“This could help us understand our previous observation that TLK depletion caused replication stress and help us exploit the effects of TLK depletion for cancer therapy,” says @ssurebayona, first author of the study, now a postdoc at @TheCrick and #IRBAlumni.
(3/4) Image
Read 4 tweets

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