Comprehensive updates on all work streams of the Therapeutics and Diagnostics divisions will be provided.
Naturally, the content will likely be dominated by the various #COVID19 products under development - and of those, many market participants... 1/n
...(esp. new holders) will only have eyes for the LFT.
I think it’s important to appreciate the number of short term traders - and nervous retail investors - there are in #AVCT at present.
In my view, the near-term SP movement (which I think will be strong, either way)... 2/n
...will be driven by one very simple - but critical - matter: whether #AVCT has been permitted to disclose in its interims the UK Gov’s involvement in the rollout of the LFT.
I think the majority will agree that that involvement is beyond question.
...is calling for 200+ million antigen tests per month (up to 10m tests a day in total) by early 2021. Needless to say, LFTs will constitute the bulk of these tests.
#AVCT’s Affimers will ensure its LFT is first-in-class, of that I have no doubt. AVCT will take the lion’s...4/n
...share of that market.
But it may be that Gov keeps #AVCT quiet until clinical validation has been completed.
It also may be that clinical validation of the LFT hasn’t even commenced yet.
In which case, we’ll also see short termers *****ing their pants and selling. 5/n
I personally am guessing that the UK Gov has asked #AVCT to produce 100m+ per month (less than half of what is needed for #Moonshot).
Assume £1 profit per test but, as per my research notes, I think it’ll be £2-£3.
How do you value a Co like #AVCT, which could be generating...
...pre-tax profit of up to £200m per month? (100m tests x £2 profit).
Needless to say, it’d take several months at least to reach 100m units of manufacturing capacity in the UK.
But the point to note is - what’s the demand, RoW, if UK demand alone is (eventually) 100m pm? 7/n
Regardless of (lack of) disclosure of UK Gov tomorrow and #AVCT’s LFT, I think that global will be in the billions of units.
I personally feel that an AIM listing can’t handle this - and that we’ll see #AVCT upgrade its listing (NASDAQ) or else get acquired... 8/n
...within 12 months max. For me, I actually think the Diagnostics div will get taken out, leaving the Therapeutics div as a stand-alone biz, with an absurd cash pile.
Looking forward to the next few months incredibly. 9/n #AVCT
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There are many stale holders who have been underwater for 18+ months, who will be happy to take some cash out now, in this ongoing cost of living crisis. That is understandable.
There will also be traders exiting, having positioned for this update.
Furthermore, the...
2/20
...wider investment community has not yet heard of, and even more so not appreciated the significance of, today's news at #AVCT.
Finally, I will state with a high degree of confidence that today's RNS opens the floodgates for numerous more updates in the near future.
Volume returning really nicely to the small cap space, which is creating excellent trading conditions.
My average holding period in the Short-term Trading Portfolio is still around 16 sessions / 3 weeks.
Seemingly contrary to many, I consider trade entries based both on..
2/18
...fundamentals (see two recent successful trades in MMAG and SPEC, with rationales for trades founded on earnings metrics), and on stories and associated sentiment (BSFA being most recent example).
I don't subscribe to only utilizing one or the other; the same way as I...
@AnEarlofWisdom Hi Earl, I can't see any of the posts, as I'm blocked by those accounts (or I've blocked!), but I've been told there's a lot of scaremongering about various things:
1) Delay in trial; 2) Dox not activating much in TME; 3) Low cash balance, and thus possible placing coming.
1/8
@AnEarlofWisdom On the contrary, except for Cohorts 1 and 2 taking longer than expected (due to patient withdrawals - nothing whatsoever to do with #AVA6000 itself), #AVCT's progress in 2022 could not be stronger.
The DE to 200mg/m2 was the ultimate target, so that nullifies point 2) ⬆️.
2/8
@AnEarlofWisdom Licensing deals for targeted oncology drugs - even those at pre-clinical stage, like 3996 - have been monstrous in recent times (e.g. $100m cash upfront for an antibody-drug conjugate, just last month ⬇️).
...substrate to FAP is so high that the concentration ratio of active doxorubicin in the tumour : healthy tissue, will negate the requirement for increase in dose size. [My view!]
Enough dox is already becoming active in the tumour micro-environment, at the current...
3/8
$SGEN specializes in antibody-drug conjugates ('ADC') - a relatively novel form of targeted cancer treatment.
@avacta's targeted cancer treatment platform, preCISION, has the real potential of generating pro-chemotherapies that are MORE targeted than ADCs, and thus...
2/6
...also potentially capable of delivering a more potent drug payload.
#AVCT will be announcing the results of the first preCISION prodrug P1 trial (AVA6000) in the next few months.
Success will mean the platform could be used to modify many other existing chemotherapies.
3/6