There has been interest in Interferon. Doubtless there will be discussion about route of administration etc
But this is the best evidence there is - and it is not encouraging.
But the big discussion will be about remdesevir.
How do the SOLIDARITY results fit will the other available information:
Overall - no effect on survival
On ventilation - no effect on survival
Not on ventilation - no clear effect on survival; consistent effect with the overall
People will argue about the need for earlier use (possibly) or that with even more data there may be a benefit (possibly - but where are those trials going to come from).
But the effect is modest at best - and so far there is no strong evidence it is there at all.
Remember, remdesevir is given by intravenous infusion for 5-10 days. It is not cheap. And supplies are limited (not surprising given scale of epidemic).
COVID affects millions of people & their families around the world. It is not a rare disease and we need scalable, affordable, and equitable treatment solutions.
The @WHO SOLIDARITY trial has done the world a huge favour by producing clear, independent evidence.
More results from the RECOVERY trial - Hydroxychloroquine:
Among patients hospitalised with COVID-19, hydroxychloroquine (HCQ) did not improve 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death
1561 patients were randomised to HCQ + usual care
3155 patients were randomised to usual care alone
in the largest randomised trial of HCQ for treatment of COVID
No evidence of benefit of HCQ on any of the pre-specified endpoints.
In patients admitted to hospital with COVID-19, lopinavir–ritonavir did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.
Lopinavir-ritonavir is an HIV treatment that was widely recommended and used for #COVID19. The RECOVERY trial has shown it does not work - so doctors no longer use it.
That’s why we do trials - to separate out drugs we think might work from drugs we know do work.