I am a bit late to this party but this is what I have to say about "Great Barrington Declaration" about COVID strategy. gbdeclaration.org translated into 24 languages here.
Two of its three authors, Sunetra Gupta and Jay Bhattacharya have separately published estimates of immunity through infection that were (a) scientifically flawed and (b) considerably higher than the truth but were most adept at getting public attention for these wrong estimates.
While the declaration itself suggests a policy without any quantitative estimates backing it up, nor indeed any caveats about in what circumstances the strategy might or might not be the best one.
To falsify their argument by absurdity, in China the current rate of infection is to essentially 0. And for the sake of argument a widely distributable vaccine is 3-6 months away.
The authors state "Those who are not vulnerable should immediately be allowed to resume life as normal." In the Chinese context, this would mean abandoning quarantining of new arrivals and the other ongoing measures that are keeping the rate of infection extremely close to 0.
This would essentially set up a race between the inevitable exponential increase of the virus and and the ability of people to shield their elderly relatives until a vaccine could be delivered to them. Plus of course the risk of long term harm to lower risk individuals.
Of course this strategy would not be the most compassionate, or indeed the most economically or in any other respects sensible approach for China. Carrying on as they are for 6 months or so while a vaccine is rolled out would obviously be better.
But the document does nothing to attempt to delineate between circumstances where the strategy might be the most appropriate one - i.e. where the costs of poorly effective attempts to suppress general transmission have become too high and circumstances where it would not.
Allowing the virus to circulate uncontrolled is a one way street. there is no going back. Its therefore *at best* a last resort that should be based on sober, conservative calculation of relative harms.
The authors have already shown that they cannot be trusted to produce these sober, conservative estimates or to communicate them appropriately.
Propagandizing for an end to control of virus circulation makes this goal harder to achieve everywhere that the document is taken seriously. In China it will be ignored but in other places especially where the virus is currently reasonably well controlled it can do real harm.
As a group, scientists like to encourage freedom of thought. Some of us are particularly talented at getting our ideas heard by saying provocative things. Unfortunately all the Great Barrington Document really is
is provocative expression of enticing ideas. Harmful trolling.

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More from @DanielFalush

14 Jul
Trump's ongoing battle of words with Fauci is a modern version of Canute's contest of wills with the sea. The worrying thing is if there is a sense in which Trump can actually win it. Such a victory would carve out a zone where facts have no import whatsoever.
Fauci has as much scientific and for that matter moral authority behind him as is practically possible in today's world and is a savvy communicator. Furthermore, he almost literally stands up for facts.
There are maybe three senses in which Trump can chip away at him. The first is in the "Fox News" sense of ignoring the weight of evidence. "sometimes I say things are at least partially right, while on some occasions Fauci has said things which were at least partially wrong".
Read 7 tweets
9 Apr
Thread. Will explain from first principles how China put itself in a good position to come out of lockdown, why it will be harder for the West and the broad principle it needs to adopt to make a smooth transition to normality feasible 1/15
The first principle is simple. You can come out of lockdown when (almost all of) the people who are infectious are separated from (almost all of) those who are susceptible, i.e. to those who have not been infected. 2/15
China started to return step by step to normal life about the same time I returned there from a trip from Europe, on February 19th. At this point there were about 350 cases in Shanghai, that were all in hospital or recovered. 3/15
Read 14 tweets
3 Apr
Why the west needs to move towards centralised quarantining, as soon as is practical. Time-critical policy threat, please retweet. 1/14 @Magda_Skipper @genemodeller @mrjamesob @piersmorgan @guardian @Telegraph
when, in early february, I heard about the plan to put coronavirus patients with mild symptoms into sportshalls, I felt uncomfortable for several reasons. I wondered about whether such facilities would provide a high standard of care. Wouldnt people do better at home? 2/14
I worried about compulsion, I worried that it implied the situation was desperate. I was not the only one worried. The measure was only implemented after an extensive discussion on Chinese social media, with a large fraction of responses expressing support for the measure 3/14
Read 16 tweets
29 Mar
OK, bugger the weekend off, here is another politely angry thread on UK policy and how it *still* does not have the right urgency to it. 1/15
The very recent Imperial paper predicted as few as 5700 deaths, with a peak of 260 in one day. There were around 260 deaths *yesterday* and the numbers are still growing by around 30% a day. 2/15
While the epidemic is still growing exponentially, there is no responsible way to predict a maximum number of deaths except to assume that everyone is going to get infected. That would imply on the order of a million deaths, given the finite supply of ventilators and medics. 3/15
Read 16 tweets
22 Mar
The "herd immunity" fiasco in UK policy making still matters in an immediate sense, because those involved it are still at the heart of the government response. So needs to be talked about now. Stress I have nothing personal against anyone and will not mention individuals. 1/12
The scientists involved just did not succeed in wrapping their heads around how serious a pathogen COVID-19 is and how it could not be business as usual any more. This is natural normal human psychology. Its really hard to break this news to a government or a country. 2/12
The herd immunity policy that resulted is a kind of collective delusion. That it could not work is obvious simply based on the brute facts on the ground in Wuhan. Somehow, sophisticated mathematical models were nevertheless bent towards the conclusion it could. 3/12
Read 12 tweets
16 Mar
Here is another way to understand how the scientists advising the UK government got their advice so wrong. All scientists are careful to say that COVID-19 is not like the flu, both because it is much deadlier and because noone has pre-existing immunity. 1/6
However the UK scientists basically tried to apply a flu-like model, emphasizing seasonality, immunity etc. Biologically, it is the most similar virus that kills many people. However, depending on circumstances, COVID-19 is approx 30 times more deadly than the flu, 2/6.
Ebola is approx 30 times more deadly than COVID-19. Unless civilization breaks down it will never directly kill many people. The reason is it is not very cryptic. As long as you pay attention and have equipment, you can stamp it out. 3/6
Read 6 tweets

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