Tweetorial on our new paper, part 1: #Thyrotropin (#TSH) concentration is elevated in post-traumatic stress disorder (#PTSD), reflecting an elevated #setpoint of #pituitary-#thyroid feedback control. doi.org/10.3389/fendo.… 
2 | TSH correlates to #allostatic load, measured by #SIQALS 2 score. Although #TSH rises, #FT4 and #FT3 concentration don't go down. Therefore, TSH doesn't reflect #hypothyroidism, but an increased setpoint due to type 2 #allostasis. frontiersin.org/articles/10.33…
3 | #Jostel's TSH index (#JTI) correlates to the #SIQALS 2 score for type 2 #allostatic_load in a large dataset of the #NHANES collective. This supports an elevated reference input (set point) of #thyroid #homeostasis in chronic #stress. doi.org/10.3389/fendo.…
4 | Instrumental variable regression helps to clarify the direction of #causality in the potential presence of endogenous regressors and feedback, confirming a direct association between #allostatic_load and #thyroid function. doi.org/10.5281/zenodo… doi.org/10.5281/zenodo…
5 | The relation of #thyroid function to post-traumatic stress disorder (F43.1) is even more pronounced if the #meta_analysis is restricted to studies with chronic #PTSD. Here, we see both increased #TSH and #FT3 concentrations. doi.org/10.5281/zenodo… doi.org/10.5281/zenodo…
6 | As seen in this meta-regression, the influence of #PTSD especially on #TSH levels is stronger if the interval to the causative #trauma is longer. The reason for this time-dependency is unclear and a task for future research. frontiersin.org/articles/10.33… figshare.com/collections/Th…
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