1/n: On the occasion of current discussions on testing strategies in #COVID19 let's make a short tweetorial on medical decision making (a branch of biomedical cybernetics, which is underestimated but has enormous impact). #cybernetics #biocybernetics #DecisionTheory 2/n: #Sensitivity, also known as "true positive rate" (TPR) is the fraction of the number of diseased subjects with positive test divided by all diseased patients. Since in both numerator and denominator are pure counts it is independent of the prevalence of the disease:

Our next paper: Abnormal #thyroid function is common in #takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study onlinelibrary.wiley.com/doi/full/10.11… In this study, we compared patients with #takotsubo syndrome (#TTS) with age- and sex-matched normal subjects from the #NHANES collective and with patients affected by acute coronary syndrome (#ACS) from the AQUA FONTIS study (@StudyAqua). Main outcome measure was serum #FT4.

Tweetorial on our new paper, part 1: #Thyrotropin (#TSH) concentration is elevated in post-traumatic stress disorder (#PTSD), reflecting an elevated #setpoint of #pituitary-#thyroid feedback control. doi.org/10.3389/fendo.… 2 | TSH correlates to #allostatic load, measured by #SIQALS 2 score. Although #TSH rises, #FT4 and #FT3 concentration don't go down. Therefore, TSH doesn't reflect #hypothyroidism, but an increased setpoint due to type 2 #allostasis. frontiersin.org/articles/10.33…