Thread by @Em23397

#longCovid #Covid19 #apresJ20 step by step..petit à petit 👉Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology - EBioMedicine. Thread🧵 👇 thelancet.com/journals/ebiom…

#longCovid #Covid19 #apresJ20 3 hallmarks of #Covid19 : [..] persistent viral infection, endothelial dysfunction [...] lung thrombosis, [..] presence of large numbers of dysmorphic cells in the lung. 👇

👆#LongCovid #Covid19 #apresJ20 Presence of abundant cytoplasmic RNA signals and expression of the Spike protein in the lungs after 30-40 days from diagnosis in our study suggests ongoing replication and postulates a continuous pathogenetic role of viral infection.👇

👆#LongCovid #Covid19 #apresJ20 [...] We propose that several of the COVID-19 unique features are due to the persistence of abnormal, virus-infected cells in the lungs for prolonged periods of time [...]👇

👆#LongCovid #Covid19 #apresJ20 [..]We wanted to assess whether the destruction of alveolar tissue and subversion of the lung microarchitecture might be consequent of persisting viral infection [...]👇

👆#LongCovid #Covid19 #apresJ20 [..] In all the SARS-CoV-2 RNA-positive patients, we found the presence of the viral genome in several of the endothelial cells lining the pulmonary vessels [...] 👇

👆#LongCovid #Covid19 #apresJ20 [...] We carefully analyzed the myocardium in additional 19/35 of the non-IC patients. In all the cases, the cardiac tissue showed variable extent of cardiomyocyte damage in both the right and left ventricles [...]👇

👆#LongCovid #Covid19 #apresJ20 [...] our data challenge the notion that viral replication has ceased in patients with advanced disease. ...[...]👇

👆#LongCovid #Covid19 #apresJ20 [...] Presence of abundant cytoplasmic RNA signals and expression of the Spike protein in the lungs after 30-40 days from diagnosis in our study suggests ongoing replication and postulates a continuous pathogenetic role of viral infection.[...]👇

👆#LongCovid #Covid19 #apresJ20 [...] In addition to persistent viral infection, at least two additional hallmarks characterize the COVID-19 pathology. First, the presence of massive lung thrombosis [...]👇

👆#LongCovid #Covid19 #apresJ20 [...] In terms of defining the underlying cause for thrombosis, we found several endothelial cells lining small and larger vessels infected with the virus [...]👇

👆#LongCovid #Covid19 #apresJ20 [...] Besides persistent viral infection, endothelial dysfunction and lung thrombosis, our study indicates that a third hallmark of COVID-19 disease is the presence of large numbers of dysmorphic cells in the lung [...]👇

👆#LongCovid #Covid19 #apresJ20 [...] Presence of abundant cytoplasmic RNA signals and expression of the Spike protein in the lungs after 30-40 days from diagnosis in our study suggests ongoing replication and postulates a continuous pathogenetic role of viral infection

@threadreaderapp please unroll