This is a speculative calculation informed by data available from Liverpool. The source is the Liverpool mayor - reported 23,170 tests done, with 0.7% positive (so about 162) here.
No sensitivity data for this test - @UKPHE has data but not public
I estimate sensitivity of 75% based on independent evaluations done for WHO of other similar LFIA tests (range from 50% to 90%) - but in symptomatic patients
There are a lot of data and studies reported - difficult to get your head round. Grateful to CI for talking to me this afternoon. He has worked at incredible speed to meet deadlines and says full report is forthcoming – there is more data and description to be added.
2/20
Phase 2 – spiked samples in controlled laboratory conditions
Phase 3a – samples from hospitals tested in controlled laboratory conditions
These do not tell us how well tests work in real world – important to do to move forward to what happens next, but pass by them now.
and I presume was on Boris’s list of the tests last night.
We are updating our Cochrane review and have been through our searches. There are no pre-prints or published studies of this test.
There are 2 studies – 1 from the company Instructions for Use (IFU) and 1 from PHE Porton Down.
Test is made by Xiamen Biotime Biotech in China.
Quick Critical appraisal of PHE Porton Down study:
1)Is the study relevant? Can’t tell.
2)What do the results mean? Can’t tell.
3)Should we believe the results? Can’t tell.
(please give us the full report!!!)
2A Test 60 spiked saliva samples (n=15x4 dilutions)+71 -ve samples
2B Test against seasonal coronaviruses
3 Lab study of 1000 negatives and 200 positives sourced by Oxford University Hospitals. -ves fresh (<48hr) saliva samples +ves frozen
“Phase 3 findings will be reported to the Oversight Group, with DHSC and ministers using this information and any recommendations to inform potential purchasing decisions.”
Little detail is public – full results below - criteria for “pass” and “fail” for Phase 3 not stated
Following from the Telegraph at the weekend, I have now seen the data from iAbra for their 20 second "Holographic microscopy" saliva test being trialled at Heathrow.
“we are in a pandemic, people are dying from the disease, and a company decides that it is reasonable to mislead us all to make their test look like the best thing available."
2/10
"Legally, they can probably get away with this, but there cannot be any consideration that this is morally acceptable.”
They have said my characterisation was “incredibly unfair”.