This is a key point that should be discussed more (if you don't understand it) or repeated more (to get it past other, now outdated paradigms).
👇👇👇
And yes. There is⏩actual evidence⏪ that small particle *aerosols* (SPA; not droplets-although I can't find the specific SPA size range in this paper) infect & result in inflammation and can generate ARDS (highlighted below were SPA infected) in primates
ajp.amjpathol.org/article/S0002-…
Some studies don't adequately discriminate larger droplets from SPAs in their "aerosol" so which was the more likely, or whether both were equally likely, cannot be determined and so the precise route remains unclear
e.g. nature.com/articles/s4158… and sciencedirect.com/science/articl…
Disappointingly - perhaps because they are influenced by the those outdated paradigms - these👆 sorts of studies, for the sake of some added distance, could contribute vitally useful new transmission data, but just fall short.😡
There is of course lots of ancillary theory & evidence for infectious aerosols (not for droplets though) being produced in daily activities, existing via lab work and *actually occuring* via capture and experiment-a good review with lots of info & links is sciencedirect.com/science/articl…
Some great expert follows on the subject of aerosols...
@Don_Milton @linseymarr @jljcolorado @ShellyMBoulder @kprather88 @CathNoakes @Lucas_Bolivian
Last link on the evidence and discussion tweet should be ohcow.on.ca/edit/files/eve…

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More from @MackayIM

9 Nov
"I am not a biologist, but have been discussing this article with a university student who is studying the field. He is questioning whether a PCR test can distinguish two viruses which differ in segments that have a few different base pairs but are of the same length"
-puts aside
I love the quality of expert who comes to comment on my blog.
"There are several millions of different viruses, but we only have a little more than 10.000 full genomes..."
-I know some head just exploded
Read 9 tweets
2 Nov
If there's a link provided, it points to an Emergency Use Only instruction document for the CDC's SARS-CoV-2 PCR (July here, may be other versions) in which there's a comment: testing had to use a viral sequence made in the lab because didn't have *quantified* virus isolates
This whole misunderstanding (I'm being generous) hinges on the word "quantified". CDC researchers *had* cultured virus (see 👇) in January & March, but they didn't have a preparation of virus in which they knew number of infectious particles present. That's the quantified bit.
When you know how many infectious particles present, you can determine the limit of the sensitivity of the RT-PCR, in those same terms. Which is nice but not essential.
You can also do this using the same viral sequence target, prepared & quantified in the lab as RNA. They did 👇
Read 19 tweets
1 Nov
Israel begins gradual easing of lockdown measures as Covid-19 cases decline
-from18OCT2020
f24.my/6zCZ.T via @FRANCE24
"“I never thought a lockdown was a healthy solution. But we reached a level of morbidity in which we had no choice,”"
theguardian.com/world/2020/oct…
Read 4 tweets
29 Oct
1580-1350 BC
An Egyptian stele portrays a priest with a withered leg, suggesting highly infectious polio has existed for thousands of years.
1916 AD
A polio epidemic on New York, USA.
The 1900s saw epidemics of polio worldwide
2020
After extensive global vaccination programs, only a handful of wild cases can be found. Africa is declared free of wild poliovirus transmission.
Regions that include 90% of the world's population are now free of wild polio.
Read 6 tweets
25 Oct
Victoria records a zero case day!!
This is after reporting a 725 case day in the peak of Wave 2, ~80 days ago.
#donutday
It can be done.
Who else has brought so many community #COVID19 cases to zero?
❓Taiwan? Never got that high
❓Vietnam? As above👆
❓New Zealand? 👆
❓Thailand? 👆
❓Singapore (almost-9 its minimum so far)
❓Switzerland (almost)
❓Israel (almost)
❓China✔
This isn't the end of Victoria's story - of course.
Vigilance will need to remain as restrictions loosen further, but this *can* be done even in an urban setting, if there is willingness to go for it - from both leadership and community.
Read 4 tweets
24 Oct
A new version with colour & division inspiration from @UQ_News and strict mouse design oversight by @kat_arden (ver3.0).
It reorganises slices into personal & shared responsibilities (think of this in terms of all the slices rather than any single layer being most important) Image
This adds stay home if sick, cough etiquette and air filtration and limit time spent in crowds (thx @cwjohannsen )
Also adds the misinformation mouse (thx to @DamianTheAussie
& @jurreysi), which may become a rat in future versions
Constructive feedback welcome.
Previous thread and more recent prior versions
Read 4 tweets

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