Alina Chan Profile picture
14 Nov, 8 tweets, 4 min read
@washingtonpost Opinion article by their editorial board.
"there are troubling questions in China that must be examined, including whether the coronavirus was inadvertently spread in an accident or spill from the Wuhan Institute of Virology" washingtonpost.com/opinions/globa…
@washingtonpost @PostOpinions I wanted to point out that the @TheLancet commission to identify COVID origins is chaired by the president of @EcoHealthNYC who has a massive conflict of interest wrt the WIV.
I have concerns regarding how rigorous and productive @TheLancet 's investigation of lab origins will be. Considering that Dr. Daszak did not even know until recently that the closest full virus to SARS-CoV-2 had been actively sequenced in the WIV between 2017-2018.
And @washingtonpost @PostOpinions re: WHO, "Nothing can be off limits, no possibilities ignored." I agree, but as it currently stands, the WHO origins team will not be allowed to even talk to the index patients or visit Wuhan/the market, not to mention the WIV lab.
So while I agree with the messaging of your opinion that finding the origins of SARS-CoV-2 is 💯critical to preventing future pandemics, I think you may have glossed over some major, possibly unsolvable obstacles to "a credible, impartial investigation".
At this point, I suspect the most likely outcome is not that we will know for sure whether this virus came from a lab or nature - but that we will never know because international investigations have been blocked on multiple fronts, and the most impt evidence is gone/unreliable.
In the absence of a credible investigation into SARS2's origins, we have to collectively operate as if each scenario = true: that SARS2 spilled over from trafficked animals, circulated in people living near bats, and emerged from lab-activities (virus collection/manipulation).
This means stronger (and effective) laws+enforcement against wildlife trafficking/habitat invasion, possibly relocating villages so people don't live in high risk spillover zones, initiating an international moratorium and ban on high risk pathogen sampling+characterization work.

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More from @Ayjchan

14 Nov
Will do a thread today explaining the different types of covid tests, how they work, and what this means for false positives/negatives. fortune.com/2020/11/13/elo…
The first thing is to see what this virus is- at its core, it stores its genetic material, RNA (no DNA). This RNA is the blueprint for all of the proteins shown in this picture: N which wraps the RNA, the spike which sticks out from the virus and binds host cells, M, E etc.
Sorry, quick caffeine break. I overestimated my Saturday morning energy levels.
Read 38 tweets
12 Nov
Accelerated Evolution of SARS-CoV-2 in an Immunocompromised Host - reading for tomorrow nejm.org/doi/full/10.10…
Being a nerd, the first thing I did was to check if all of the spike mutations in the covid patient with "accelerated evolution" have been detected before in the 200K+ SARS-CoV-2 genomes on @GISAID using the @CovidCg browser covidcg.org
nejm.org/doi/full/10.10…
The answer is yes, all of the spike mutations shown in their figure except for N440D have been seen before, albeit there are other mutations at N440 (Y or K) that have been detected.

🤟@atchen_ for designing these SNVs to look like jellybeans @CovidCg covidcg.org Image
Read 6 tweets
10 Nov
Tough questions about the #pangolinpapers and the peer review process in this investigative article by the @USRightToKnow

At least half a dozen people on twitter bombarded me with this article today for good reason...
It relates to the curiosity of all of these #pangolinpapers being released on Feb 18-20, driving a mania that SARS2 came from pangolins; all 4 papers used the same 2019 dataset; there is a web of co-authorship (scroll to end of the thread cited here):

I'm saving a 🔥🐉 thread on the issues in these papers for when their corrections are issued. But key questions raised by @USRightToKnow (I'm paraphrasing):

1. Did these authors know about each other preprinting in the same 3 days (3 groups on Feb 20, 1 group on Feb 18)?
Read 12 tweets
9 Nov
Well-rounded reporting on the Pfizer mRNA vaccine.

What did they find? What are the outstanding questions? What clinical trial data are we waiting to see in the coming weeks?

statnews.com/2020/11/09/cov…
After vaccines are developed, there are still hurdles to returning to normal. (1) Vaccination compliance; if few people are vaccinated, this doesn't result in herd immunity. Some individuals also don't develop lasting immunity in response to the vaccine...
vaccinestoday.eu/stories/why-do…
Let's say only a 50% of states have widespread vaccination, you'll still have to think about interstate & international travel in terms of whether you're traveling to a place where there is no herd immunity and the risks of you getting sick there even if you have been vaccinated.
Read 6 tweets
9 Nov
Thorough article by @GMWatch about the conflict of interest and lack of accurate information coming from EcoHealth on the topic of SARS2 origins - but you forgot to mention the karaoke parties and spelunking parties...
“Right now a party in a bat cave sounds just right to me!!” - Peter Daszak
Please do not allow EcoHealth to visit any more bat caves. The last thing we need is SARS2 being accidentally given to bats in the wild (like the mink farms). Bats already have a great virus reservoir going on, no need to add human viruses with novel features to their inventory.
Read 8 tweets
9 Nov
9-page Nov 5, 2020 meeting report: WHO-convened Global Study of the Origins of SARS-CoV-2

What is the @WHO approach to investigating the origins of SARS2? Possibly the biggest mystery of our lifetime.

who.int/publications/m…
The report is dated "31 July 2020" on page 1 so this has been a work in progress for at least 3 months.

Phase I: Wuhan may not have been where the outbreak started; we need to examine the Dec 2019 cases to see if there are links to other parts of China and other countries.
Current knowledge: "the virus has been remarkable stable since it was first reported in Wuhan, with sequences well conserved in different countries, suggesting that the virus was well adapted to human transmission from the moment it was first detected."
Read 21 tweets

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