One option is IP6: How Should Pharmaceutical Companies and Patients Served By Health Systems Share the Value Generated By New Medicines? with Danny Palnoch from @NHSEngland, @bs_woods from @CHEyork, Jens Grueger from @UW_Pharmacy and Patricia Danzon from @Wharton#ISPOREurope
Or SP2: Is Credible, Robust Real-World Evidence Just a Myth? with Anja Schiel at Norwegian Medicines Agency, Xavier Kurz at @EMA_News, Nancy A Dreyer from @IQVIA_global and Robert Golub from @JAMA_current #ISPOREurope
Or W2: Methodological and Normative Issues Arising in Recently Updated National Guidelines for Economic Evaluation, with @mfosoares and @MJSculpher from @CHEyork, Conor Teljeur at @HIQA and Ian Watson at @NICEComms #ISPOREurope
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I'm now live tweeting from the #ISPOREurope session Much Ado About Little: Dealing with Limited RCT Evidence for Early HTA and Reimbursement Decisions with @MJSculpher, @SBujkiewicz, Eva Dietrich, Steven Palmer from @CHEyork, and @UweSiebert9
When do we need causal inference methoss? when there's no randomisation; or the randomisation was broken (e.g. treatment switches)
Throughout his talk, Uwe will use the example of 2nd line treatment in women with ovarian cancer who progressed #ISPOREurope
Next, live from #ISPOREurope IP8: Integrating Patient Preference into Health Technology Assessment- Can Patient Preferences be Incorporated into the ICER? w/Esther de Bekker-Grob @erasmusuni, Kevin Marsh @evideraglobal Mendwas Dzingina @pfizer & @JacolineBouvy at @NICEComms
Esther de Bekker-Grob starts with the questions addressed in this panel
The background is that, given the increased focus on pt preferences, #HTA should not fall behind
Why should #HTA consider pt preferences?
To improve adherence, to increase pt satisfaction, to make HTA decision making more informed & transparent, and it is ethical to listen to the pt voice.
To start, @juliaslejko presents the context for the @ISPORorg#WomenInHEOR initiative.
There is evidence that diversity pays off in terms of companies' profitability. But women are under-represented, and there is a leaky pipeline in academia #ISPOREurope
@ISPORorg board members and staff are quite diverse. What about ISPOR conferences, like #ISPOREurope?
Gender diversity has improved in ISPOR conferences 👏
But there is still some way to go - that's ISPOR intention and aspiration
Jack Ishak starts by introducing panellists and setting the motivation for this panel: therapies that have raised the potential of cure, given the plateau since in the OS and PFS curves #ISPOREurope
This raises analytical challenges on how to project the OS and PFS curves over the long term. Mixture cure models have been used. Here, the curve is a weighted average of the survival of cured and uncured, where the weight is prop cured. #ISPOREurope
Laura starts with what her presentation will cover:
1-What is a #CostEffectiveness#Threshold for?
2-What should it reflect?
3-How to estimate it empirically?
4-What are the consequences of setting the decision threshold at != from empirical threshold? #ISPOREurope
What is a #Threshold? It is to find out if an intervention generates more benefits gained than lost via the opportunity cost, AND/OR to identify a decision threshold that incorporates other policy objectives. #ISPOREurope