NY CRISPR research group claims to have IDed genes that can protect human cells against Covid-19 and three drugs effective at “stopping viral entry in human LUNG cells” (emphasis added):
Amlodipine
Tamoxifen
Ilomastat

cnbc.com/2020/11/20/cri…
RE Tamoxifen - last month:

COVID-19 infection can cause chemotherapy resistance development in patients with breast cancer and tamoxifen may cause susceptibility to COVID-19 infection

ncbi.nlm.nih.gov/pmc/articles/P…
Tamoxifen causes down-regulation, mutation, or loss of estrogen receptors.

AND

“We determined that the frequency of COVID-19 infection is more common in patients with breast cancer than other types of cancer.”
“Estrogen can have a protective effect against COVID-19. Estrogen increase causes ER-α upregulation in T lymphocytes. Thus, estrogen increases the release of interferon I and III from T lymphocytes. Increasing interferon I and III alleviates COVID-19 infection.”
Then there’s protective correlation with mumps per @CIDRAP

“Epidemiologic data point to low COVID-19 death rates in populations with high MMR vaccination rates, but the mechanism of protection is still unclear.”

cidrap.umn.edu/news-perspecti…
“The researchers found a significant inverse correlation (-0.71, P < 0.001) between levels of mumps antibodies and COVID-19 severity in the MMR group.”
So how can Tamoxifen “help” according to one set of researchers and “hurt” according to another? And why was MMR not part of CRISPR research?

@Rebecca4Georgia
@Single_Shot
@CT_Bergstrom
@trvrb
Looking for something other than @CNBC story about CRISPR work

And an explanation of how you could give Amlodipine to someone with normal BP. It’s half of my BP meds (three years of Anastrozole will do that if at genetic risk)

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More from @kegill

23 Nov
Sunday 22 November front pages ... a 🧵 ... amazing/disturbing how many DO NOT feature COVID

Starting with @NYDailyNews
Read 37 tweets
22 Nov
This is outrage porn.

IT IS NOT HELPING.
It feeds Trump's need to be center of attention.
It amplifies lies.
It makes Trump supporters feel validated in their distrust of the election.
It diverts attention from the SHIT that is going on during lame duck.

JUST SAY NO. Image
By amplifying his lies, NEWS MEDIA are enabling Trump's lame duck efforts to undermine voter confidence in the integrity of our elections.

NEWS MEDIA are enabling Trump's "fiddle while Rome burns" approach to COVID19.
NEWS MEDIA HAVE enabled Trump's super-spreader behavior by the way they covered his "rallies" and "events".

WHAT'S THE STATUS OF THE INVESTIGATION INTO TRUMP'S USE OF THE WHITE HOUSE ON ELECTION NIGHT?

reuters.com/article/us-usa…
Read 7 tweets
22 Nov
You have to be shedding enough for tests to work. “About 40% of infections are spread by asymptomatic people with high viral loads” - but without symptoms, they are unlikely to be getting tested. @propublica
Quick tests as used in the US are very flawed. They throw false positives as well as false negatives.

“anyone who gets a single negative result shouldn’t use it as an excuse to go to a bar” or anywhere for that matter

@lisalsong

propublica.org/article/rapid-…
HHS has directed nursing homes “to use [antigen tests] off-label, in a way in which they were untested and unproven.”
Read 6 tweets
21 Nov
This analysis from @MattGrossmann is the first I’ve seen to suggest the GOP could retake the House in 2022. Post-census gerrymandering by red-state legislators remains a real threat despite delays.
It is imperative that the House of Representatives be enlarged.

Congress set the number of Representatives at 435 in 1911, when our population was 28% of today’s (93M v 331M).
The founders thought a House member should represent 30K people. (We’ll ignore slavery for the moment.)

In 1911, it was 200K people.

Today it’s about 760K.

nytimes.com/interactive/20…
Read 5 tweets
21 Nov
Why are news media amplifying Trump’s continued refusal to concede?
TRUMP’S NOISE masks the fruits of his deliberate thwarting of COVID public health efforts.

THIS HEADLINE is his legacy. MSM should devote their political coverage to COVID.

npr.org/sections/healt…
And I do NOT mean rosy, breathless and context-bare hype about COVID vaccines.

It’s HYPE (just look at stock prices) and any widespread distribution to average Americans is far in the future.
Do you REALLY think almost half of America (per polls) would be traveling and holding multi-family Thanksgiving dinners if we had ONE CONSISTENT PUBLIC HEALTH MESSAGE ABOUT COVID RISK?
Read 5 tweets

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