Thread by @kegill

NY CRISPR research group claims to have IDed genes that can protect human cells against Covid-19 and three drugs effective at “stopping viral entry in human LUNG cells” (emphasis added):
Amlodipine
Tamoxifen
Ilomastat

cnbc.com/2020/11/20/cri…

RE Tamoxifen - last month:

COVID-19 infection can cause chemotherapy resistance development in patients with breast cancer and tamoxifen may cause susceptibility to COVID-19 infection

ncbi.nlm.nih.gov/pmc/articles/P…

Tamoxifen causes down-regulation, mutation, or loss of estrogen receptors.

AND

“We determined that the frequency of COVID-19 infection is more common in patients with breast cancer than other types of cancer.”

“Estrogen can have a protective effect against COVID-19. Estrogen increase causes ER-α upregulation in T lymphocytes. Thus, estrogen increases the release of interferon I and III from T lymphocytes. Increasing interferon I and III alleviates COVID-19 infection.”

Then there’s protective correlation with mumps per @CIDRAP

“Epidemiologic data point to low COVID-19 death rates in populations with high MMR vaccination rates, but the mechanism of protection is still unclear.”

cidrap.umn.edu/news-perspecti…

“The researchers found a significant inverse correlation (-0.71, P < 0.001) between levels of mumps antibodies and COVID-19 severity in the MMR group.”

So how can Tamoxifen “help” according to one set of researchers and “hurt” according to another? And why was MMR not part of CRISPR research?

@Rebecca4Georgia
@Single_Shot
@CT_Bergstrom
@trvrb

Looking for something other than @CNBC story about CRISPR work

And an explanation of how you could give Amlodipine to someone with normal BP. It’s half of my BP meds (three years of Anastrozole will do that if at genetic risk)

Here’s link to research (missing from @cnbc story

https://twitter.com/nevillesanjana/status/1320074733136826368?s=21

https://twitter.com/nevillesanjana/status/1320074733136826368