1/ A bat-derived coronavirus (CoV) starts an outbreak near a bat CoV research center, the Wuhan Institute of Virology (WIV) 2/ WIV's virus database is noticed to be offline
15/ These *facts* call into serious question one of the main arguments against a lab scenario: that no SARS-2-like viruses existed at the WIV before the Wuhan outbreak
1. While awaiting @shingheizhan reassembling of RaTG13, here's a thread with some odd features reported by authors who made use of its GenBank sequence. Most of them used the sequence for other research goals, rather than assessing it, so its anomalies are mentioned incidentally.
2. This Feb 2020 preprint found that synonymous mutations "are dramatically elevated between SARS-CoV-2 and RaTG13" and "enriched in T:C transition."
Since some RNA mutagens "could induce the same mutation pattern", authors suggest further investigation. biorxiv.org/content/10.110…
3. @Nerdhaspower's was the first paper I read raising doubts about RaTG13 sequence.
Issue: two bat CoVs show nonsyn mutations evenly distributed along their S sequences. For RaTG13 vs SARS-CoV-2 they appear heavily concentrated around codons 300-500. Why?