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Eric Feigl-Ding Profile picture
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25 Nov, 4 tweets, 2 min read
NEW—Trial of Hydroxychloroquine post-exposure in Spain for prevent onset of #COVID19: results found a big fat null. Nothing. Zip. Zilch. Again. Checked many subgroups too.

We have wasted so much energy and time goose chasing this. But important to debunk. nejm.org/doi/full/10.10…
2) I’ve spent what feels like eternity now debunking HCQ. So here it is hopefully for the last time... thread 🧵 on all almost trial studies HCQ.
3) Another earlier HCQ prevention trial. nothing burger 🍔
4) Here is another review of HCQ. Regarding azithro+HCQ, that’s debunked too. For zinc, there’s wild speculation but no zinc+HCQ advocates have shown a trial yet. In god we trust, all else bring *good* data.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
26 Nov
Dosing error led to Oxford AZ vaccine 90% efficacy: “error in the dosage was made by a contractor—once discovered, regulators were immediately notified & signed off on the plan to continue testing in different doses.”

Does it still count? Maybe. #COVID19
nytimes.com/2020/11/25/bus…
2) Having done trial epidemiology, it really depends how they analyzed the data after the 2-dosing regimens. Presumably the 90% from comparing the same sample who were randomized either to the low dose & the placebo of the low dose. If same 🍎 to placebo of 🍎 group, then valid.
3) However, if they analyzed all the placebo participants as a common pool used for comparison vs both the vaccine doses, then it might be biased. But anyone with good clinical trial epidemiology training would know not to do that. But only the full report would tell us.
Read 7 tweets
Eric Feigl-Ding Profile picture
26 Nov
Mind boggling:

📌CEO of largest health system in North Texas says they will have no more ICU beds soon. “We will likely be out of ICU beds in about a week”.

📌One nurse lives in hotel & sent kids away to protect for **months**. Such sacrifice. #COVID19 wfaa.com/article/news/h…
2) we don’t want this, nobody does:
3) Because this will happen soon enough too if not careful.
Read 4 tweets
Eric Feigl-Ding Profile picture
24 Nov
Public health warnings: “Don’t travel for Thanksgiving holidays.”

Americans: “hold my beer”.

#COVID19
2) we honestly shouldn’t hold any Thanksgiving gatherings. But if you must, or already committed (never too late to cancel), make sure you ventilate your home sufficiently—but this is not zero risk. The better option is outdoor gathering only.
3) Personally, I’m not gathering for thanksgiving. But if I were to, I would only do it outdoors. That is the safest honestly. Wear jackets and use heat lamps. Image
Read 7 tweets
Eric Feigl-Ding Profile picture
24 Nov
📍BAD UPDATE—14 morgues—El Paso has to expand another 5 mobile morgues & plan to build a new refrigerated warehouse w/ **3000 square feet of refrigeration** to handle the surging of deceased bodies that need medical examination, amid the #COVID19 surge. 🧵
kfoxtv.com/news/coronavir…
2) “I don’t know what else we could do. I’m really focusing on a moral appeal to our community,” El Paso County Judge Ricardo Samaniego said.

“As soon as we get one solution, it’s not sufficient,” Judge Samaniego said.
3) “The deadly impact of COVID-19 on El Paso reached an all-time high on Monday, with more than 250 bodies now being held at the county morgue, part of over 480 total deaths under investigation for the coronavirus.”
Read 8 tweets
Eric Feigl-Ding Profile picture
24 Nov
My take—I personally think the Oxford AstraZeneza #COVID19 vaccine at 90% efficacy (with its half-then-full dose regimen) simple refrigeration vaccine that costs $2.5-4/dose is superior. Cheaper + much easier to ship ➡️ means save more lives worldwide.
2) For the record, we need to stop quoting the 70% efficacy number. It’s a mix of regimen 1&2, which is not possible in the real world. You only take either 1 or 2, not both. Thus it’s either 90% or 62%. Many new outlets made this error, which I myself at first read. 90% folks!
3) Eventually, I think all 3 vaccines might be in the 90% ballpark for efficacy once more data comes out. Also Oxford vaccine reported also asymptomatic infections. While Pfizer did not—only symptomatic. Because asymptomatic can also spread it, I think that is key.
Read 4 tweets
Eric Feigl-Ding Profile picture
23 Nov
UTTERLY SOBERING—cases rising so fast that we will likely see 3000 deaths a day by end of year. That is one 9/11 ✈️✈️✈️✈️ death toll *per day*!

➡️ Christmas 2020 🎄might be cancelled if this keeps up.

(Analysis by my FAS Team). #COVID19
2) We can add more beds but we can’t just add more doctors and nurses. Especially if they keep falling ill or dying.

N Dakota is now asking infected doctors to keep working.

Thousands of doctors and nurses not so lucky.
3) Horrendous thing is that many places like the Dakotas have even given up on contact tracing.
Read 5 tweets

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