Hi @ajpollard1 @OxfordVacGroup !
What does "ChAdOx1 vector is modified to be replication deficient" mean?
Can it induce production of antigen proteins if it doesn't replicate at all?
Does the lack of replication reduce the immune response to the vector?
1/3
What does "ChAdOx1 vector is modified to be replication deficient" mean?
Can it induce production of antigen proteins if it doesn't replicate at all?
Does the lack of replication reduce the immune response to the vector?
1/3
Are ChAdOx1 vector vaccines contraindicated where live virus vaccines are contraindicated (and why [not]?)
Where can we find a New Scientist level explanation of these things?
2/3
Where can we find a New Scientist level explanation of these things?
2/3
If it is "replication deficient", how do you produce it? Can you culture it?
Parenthetic thought:
Are viruses ever "live", and where does this vector vaccine fit? Is it a Schrödinger's virus, alive or dead, depending on your reason for asking?
3/3
Parenthetic thought:
Are viruses ever "live", and where does this vector vaccine fit? Is it a Schrödinger's virus, alive or dead, depending on your reason for asking?
3/3
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