Jon Deeks Profile picture
3 Dec, 5 tweets, 3 min read
Mass testing in Liverpool MISSED ~50% of infections and ~30% with high viral loads. Results are in this Government document, but no actual numbers or details are given.

Absolutely URGENT that @DHSCgovuk reports full data today and HALTS IMPLEMENTATION

gov.uk/government/pub…
This test is NOT FIT FOR PURPOSE for the Government's plans

It is totally unsafe to use these tests to decide somebody does not have COVID nor “infectious”.

If it were a drug surely this would warrant an immediate withdrawal from use.
Missing 30% with high viral loads is NOT SAFE. PHE studies said missed <5% - so this is more than 6 times as many.

You cannot risk people with high viral loads visiting their elderly relatives.
A sensitivity of 50% means that somebody who has a negative result will have half the risk of having COVID.

PHE studies included a 58% result - but Matt Hancock denied this existed last week.

This is still a lot of risk.
PLEASE PLEASE @MattHancock @BorisJohnson @SMHopkins @didoharding @CMO_England

STOP USING THESE TESTS FOR PURPOSES WHICH PUT PEOPLE AT RISK. YOUR OWN DATA SAYS IT IS HIGH RISK. MANUFACTURER SAYS DON’T DO IT, WHO SAYS DON’T DO IT, SCIENTISTS SAY DON’T DO. IT IS A MISTAKE.

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More from @deeksj

4 Dec
So the next new Covid-19 testing technology to look at is the OPTIGENE LAMP test - as covered here in the Guardian.

1/13

Experts question claimed accuracy of Covid-19 saliva tests theguardian.com/world/2020/dec…
The main body of the report is here, appendicies with data tables can be obtained by email

2/13

gov.uk/government/pub…
The study looked at using the test on RNA extracted from swabs and saliva, and directly on swabs and saliva. Key results are here:

3/13 Image
Read 13 tweets
24 Nov
@BBCr4today invited me to speak about lateral flow tests this morning (can listen at 0650). All government plans are now about using tests to "release" people - this depends on reliability of negative result. This is what the manufacturer says:

1/16
The PHE Porton Down - Oxford University report included this graph showing sensitivity would be 58% when the test is delivered by a trained test-and-trace centre staff member. This is in symptomatics - not asymptomatics.

2/16
The Government's 77% sensitivity combines the other two groups - tests done by Porton Down lab staff, and tests done by NIHR Research Nurses - i.e. the experts and completely ignores the 58% group. That seems completely wrong.

3/16
Read 16 tweets
11 Nov
INNOVA test – time for critical appraisal of the report

What does the report say about the test and should we believe it?

1/20

ox.ac.uk/sites/files/ox…
There are a lot of data and studies reported - difficult to get your head round. Grateful to CI for talking to me this afternoon. He has worked at incredible speed to meet deadlines and says full report is forthcoming – there is more data and description to be added.

2/20
Phase 2 – spiked samples in controlled laboratory conditions

Phase 3a – samples from hospitals tested in controlled laboratory conditions

These do not tell us how well tests work in real world – important to do to move forward to what happens next, but pass by them now.

3/20
Read 21 tweets
10 Nov
How well is the Innova test working in Liverpool?

This is a speculative calculation informed by data available from Liverpool. The source is the Liverpool mayor - reported 23,170 tests done, with 0.7% positive (so about 162) here.

liverpoolecho.co.uk/news/liverpool…
Presume specificity 99.6%

No sensitivity data for this test - @UKPHE has data but not public

I estimate sensitivity of 75% based on independent evaluations done for WHO of other similar LFIA tests (range from 50% to 90%) - but in symptomatic patients

finddx.org/covid-19/sarsc…
Using a prevalence of 400 per 100,000 you get the following 2x2 table:
Read 5 tweets
1 Nov
How well will these 15-minute rapid tests Boris mentioned work? (quick answer – we don’t know)

The Innova test was mentioned this week in Telegraph.
telegraph.co.uk/news/2020/10/1…

and I presume was on Boris’s list of the tests last night.
We are updating our Cochrane review and have been through our searches. There are no pre-prints or published studies of this test.

There are 2 studies – 1 from the company Instructions for Use (IFU) and 1 from PHE Porton Down.

Test is made by Xiamen Biotime Biotech in China.
Quick Critical appraisal of PHE Porton Down study:
1)Is the study relevant? Can’t tell.
2)What do the results mean? Can’t tell.
3)Should we believe the results? Can’t tell.
(please give us the full report!!!)
Read 11 tweets
1 Nov
The PM claimed that they have validated these new 15min antigen tests – what is the @dhsc @phe validation process?

15 Aug ministers commissioned new process at PHE Porton Down in collaboration with Oxford University. Protocol here (updated 23 Oct).

gov.uk/government/pub…
3 phases:

1 document review

2A Test 60 spiked saliva samples (n=15x4 dilutions)+71 -ve samples

2B Test against seasonal coronaviruses

3 Lab study of 1000 negatives and 200 positives sourced by Oxford University Hospitals. -ves fresh (<48hr) saliva samples +ves frozen
“Phase 3 findings will be reported to the Oversight Group, with DHSC and ministers using this information and any recommendations to inform potential purchasing decisions.”

Little detail is public – full results below - criteria for “pass” and “fail” for Phase 3 not stated
Read 6 tweets

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