1/This week in @journaljgim: “Promoting Patient-Centeredness in #opioid Deprescribing: a Blueprint for De-implementation Science”

Tools of “deimplementation science” should guide evaluation of health care changes - w/@BethDarnall @AllysonVarley
link.springer.com/article/10.100…
2/Opioid prescribing has ⬇️37% since its peak in 2011. Today, many agencies agree that “deprescribing” was not carried out in ways that consistently protected patients.

We ask “how can well-intended changes to care transpire in ways that are unsafe or harmful?” 2019 CDC Surveillance Report, IQVIA data
3/De-implementation= “reducing or stopping practices that are ineffective, unproven, harmful, overused, or inappropriate”
With opioids, that could be not starting, stopping or reducing.For us, this does *not* reflect a commitment to opioid elimination from care.h/t @VPrasadMDMPH
4/Implementation scientists ask: “how and why efforts to change health care delivery succeed or fail.
It's *not enough* to ask whether prescriptions have declined
*It's better to ask "how reductions were made to happen and what the impact was on patients with pain” #ChronicPain
5/Headlines, press releases, news coverage on Rx opioids treat "pill count dynamics" as the be-all & end-all

To us, a change to care is worth it only if carried out in such a way as to achieve protection of patients. That principle is honored mostly in the breach, sadly
6/But we have tools to do better. Scientists who study healthcare system change assess those efforts by looking at 5 domains from a model called “Consolidated Framework for Implementation Research”.
Let's walk this through with opioid Rx's #CFIR cfirguide.org
7/Domain 1: Characteristics of Individuals – this includes professionals’ training in pain care, comfort with patients, and their ability to withstand external professional pressures and more cfirguide.org/constructs/cha…

Our studies ignore this at their peril
8/Domain 2 of #CFIR is the Intervention: “What letters, orders, policies, resources, supports, or other actions were used to change pain care & opioid prescribing?"–reporters & scholars leaders should ALWAYS report if their interventions were across the board or *individualized*
9/Domain 3 is "Inner Setting":organizational culture.
Do leaders use threats or rewards to⬇️opioid Rx's?
Does the culture of an organization permit safe expression of concern about harm to patients?

In a @TEDx talk, a leader rebuffed suicide concerns
10/Domain 4 of #CFIR is Process: what health care changes were carried out? what resources allocated?Who was consulted? & how the process was changed? Much of today’s research & journalistic reporting tell only about “pill dynamics”, i.e. “too much!” “too little!”
11/Domain 5 of #CFIR is Outer Setting. In part this domain asks to what extent is a planned change to care delivery is aligned with the needs and context of the patients we wish to serve, including disability & logistics!
12/ The Outer Setting also includes *external policies*, including quality metrics from @NCQA, thresholds for payment decisions tied to 90 MME. Most ignore CDC Guideline’s distinction between doses forced down vs not escalated, and ignore the clarifications from CDC and HHS.
13/A warning: external policies are NEVER completely rational, for 2 reasons

1]decision-makers cannot fully absorb problems they are called upon to solve (“bounded rationality”).

2]policy is not put into effect by one party, but many, including regulators, even journalists
14/We offer a better slate of measures of success (for successful de-implementation). It’s not sufficient to just ask how many fewer opioid prescriptions are written. We offer "better metrics" for health systems & insurers and @NCQA Proposed "enhanced metrics"
15/"Implementation science points toward a
reappraisal of how our health system responses to the opioid crisis can become more effective, holistic, and patient centered."

We're proud to be part of @vahsrd @StanfordPain @UMass @UABNews
Read more here: link.springer.com/article/10.100…

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More from @StefanKertesz

11 Dec
We are eager to hear the plenary speaker for @US_ASP (the new academic pain org for the US) Dr. Meghani of U.Penn Nursing.. on the "Guideline Epidemic and Pain Care" introduced by @JessicaMerlinMD @DrJohnPereira /1
Key points for Dr. Meghani:
*US fighting its drug war "like other resource poor countries"
*Broad misapplication of the 2016
@CDCgov
opioid guideline
*Seriously undermined care of patients with mod to severe pain
*Obligations of policy makers in scaling high policies /2
Key points made by Dr. Meghani, of U Penn Nursing for
@US_ASP
Insurers and states acted rapidly, in 2016-17 after
@CDCgov
, to impose hard #opioid dose limits, to require opioid stoppage and taper, all in apparent violation of the Guideline, which had a low evidence GRADE /3
Read 5 tweets
10 Dec
1/Bravo to Dr. @BethDarnall for stating (and better, helping lead a trial) ethical principles of a taper in which the patient is the agent, it's voluntary, and dose might go UP too. Thank-you @OldHeadFighta for the image in the next Tweet that captures the ethics here
2/Yes yes @OldHeadFighta - this gets at the reality that the principle is here is not just clinical but ETHICAL (and then I'll get to ethics)
3/The obligation upon clinicians is to treat the people in our care as full-fledged. Don't treat patients as means to an end, we wrote. Mandated dose reductions of opioids are "Not Justifiable Clinically or Ethically": pubmed.ncbi.nlm.nih.gov/32631183/
Read 4 tweets
9 Dec
Plenary: "The Evolving Relationship of Opioid Prescribing with Opioid Overdose and Suicide" - this topic will be presented of the new @US_ASP now by @AmyBohnert of University of Michigan - I'll share some points as they arise /1
Dr. Bohnert indicates she will focus more on overdose than on suicide because the combination of topics might exceed the time (and it would help to have suicide experts) /2
Opioid Rx and benzo Rx have been declining - for awhile, and for high-dose prescribing, etc. all of it is heading down @BrianMannADK of NPR please take note /3
Read 16 tweets
11 Nov
1/Last week we launched CSI:OPIOIDs, our research survey for bereaved families+friends who have lost a person with pain to suicide during a change in opioid prescribing. I want to say why this matters (fyi: it's at go.uab.edu/csiopioids ,or type URL if click-thru fails). First:
2/The recruitment letter approved by our ethical review board at @UABNews (called an IRB) is here: drive.google.com/file/d/19BRmWH…
3/Our team is inspired by the work of patients and families who have already come forward and spoken about this serious issue. We have been inspired by the painstaking efforts of people like @PainPtFightBack to record every death that comes to light.
Read 23 tweets
10 Nov
1/this study shows a massive shift to video and especially telephone care among Veterans after March of 2020. And it leaves me with key questions for vulnerable populations
2/The striking thing is not just the upsurge in non-face-to-face care but the reality that most of it was telephone 📞 only. What does that mean?
3/First in any safety net system lots of the people we wish to serve are older and poorer and potentially less comfortable with using video tech, or they may well lack the data plan and devices
Read 10 tweets
30 Sep
1/Canadian provinces that reduced #opioid prescribing the most also had the LARGEST increases in opioid overdose mortality in the 2-year period of 2016-2018 (r=0.63, p=.05, df=8) -it's striking to see significant correlations with n=10! bmcpublichealth.biomedcentral.com/articles/10.11…
2/The authors suggest that reductions in prescribed opioids create "supply gaps" that push the *non-medical opioid users* to riskier supplies.

However, I've become more concerned that some actual medical users (i.e. pain patients) also make that jump... like this:
3/In this Colorado case-control study, chronic opioid recipients who later developed new-onset heroin use were more likely to have had their prescription opioids stopped (38%) compared to those who didn't develop heroin use (22%) - sciencedirect.com/science/articl…
Read 8 tweets

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