Global vaccine news: COVAX says deals are in place to access nearly 2 billion doses of #covid19 vaccine. "For the vast majority of these deals, COVAX has guaranteed access to a portion of the first wave of production, followed by volume scales as further supply becomes available”
The new deals include:
- an advance purchase agreement with AstraZeneca for 170 million doses of the AstraZeneca/Oxford candidate
- a memorandum of understanding (MoU) with Johnson & Johnson for 500 million doses of the Janssen candidate (investigated as single dose vaccine)
That’s on top of:
- agreement with Serum Institute of India for 200 million doses (plus option for 900 million more doses) of either AZ or Novavax vaccine
- statement of intent for 200 million doses of Sanofi/GSK vaccine candidate
This "will enable all participating economies to have access to doses in the first half of 2021, with first deliveries anticipated to begin in the first quarter of 2021 – contingent upon regulatory approvals and countries’ readiness for delivery."
The agreements mean "that all 190 countries and economies participating in COVAX will be able to access vaccines to protect vulnerable groups in their populations during the first half of next year”, says @DrTedros. "This is fantastic news and a milestone in global health."
@DrTedros “Our message to all countries is that vaccines will complement not replace the existing effective tools we have for suppressing transmission and saving lives”, says @DrTedros.
@DrTedros "This is a time for taking comfort that the end of the pandemic is in sight but taking care that we do not let down our guard”, says @DrTedros.
@DrTedros On top of the mentioned deals, COVAX has "also secured first right of refusal of more than a billion doses of vaccine that could become available in 2021”, says @cepi CEO @DrRHatchett. “Equitable access is what will enable us to win, and to defeat the pandemic."
@DrTedros @cepi @DrRHatchett "We still need more doses. And yes, we still need more money”, says @GaviSeth. “But we have a clear pathway to securing the initial 2 billion doses and then beyond that that we need to end the acute stage of this pandemic."
@DrTedros @cepi @DrRHatchett @GaviSeth This is something to watch:
"Today we published principles on dose sharing to allow some countries to share doses from their bilateral agreements with the COVAX facility”, says @GaviSeth. "This will allow us to access even more doses even sooner."
@DrTedros @cepi @DrRHatchett @GaviSeth “Success next year will depend, not just on the ability to grow the portfolio or raise necessary funding, but on the readiness of countries ...to deliver”, says @GaviSeth. Much done already on this, he says. “But this will continue to be an area of focus now and into early 2021."
@DrTedros @cepi @DrRHatchett @GaviSeth Q on lack of approved mRNA vaccines in deals.
“We're certainly in discussions with Pfizer and Moderna. We're hoping to be able to reach agreement with them”, says @DrRHatchett. "But we were not ready this morning ... I would say watch that space.”

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More from @kakape

19 Dec
“We urge governments throughout Europe to agree on clearly formulated common goals, coordinate their efforts, develop regionally adapted strategies to reach the goals, and thereby work resolutely towards low case numbers”, @CiesekSandra, @ViolaPriesemann and others in @TheLancet
The lack of a European strategy is something scientists and public health experts have pointed out again and again and it’s good to see it clearly formulated by a group of prominent researchers thelancet.com/journals/lance…
The authors also give a good, succinct summary of arguments for going for low #covid19 case numbers:
1. saving lives
2. saving the economy
3. control is more effective
4. makes TTI feasible
5. natural acquired herd immunity is not an option
6. no need for rapid policy changes
Read 4 tweets
19 Dec
Meine Kollegen vom @pandemiapodcast und ich haben viele Fragen bekommen in den vergangenen Wochen zu den neuen Impstoffen, zu ihrer schnellen Entwicklung, ihrer Sicherheit, zu Impfbereitschaft und Impfpflicht. Wir wollten das natürlich aufnehmen.
@pandemiapodcast Die neue Folge ist darum ein etwas wilder Ritt querfeldein und wir binden zusammen, worüber wir in den ersten Folgen der zweiten Staffel gesprochen haben: Impfstoffe, Pocken, Masern und eben #SARSCoV2. Die Folge gibt es hier: viertausendhertz.de/pan16/
Als Nächstes dann Gelbfieber!
@pandemiapodcast Vielen lieben Dank an @florian_krammer, @CorneliaBetsch, @Karl_Lauterbach, @NatalieGrams und Sidney Chalhoub, die sich alle viel Zeit genommen haben, um mit uns für die Folge zu sprechen.
Read 4 tweets
18 Dec
Science asked me to -briefly- reflect on what happened in 2020. So, a thread on this year in science, the breakthroughs and breakdowns and where my head is at at the end of this difficult year.

Story is here:
vis.sciencemag.org/breakthrough20…
First, read @sciencecohen's beautiful, personal story on the vaccines:

“I can stop worrying about my mom dying alone in an intensive care unit, away from all who love her. And she can stop asking whether I’ll let her play mahjong with the girls”

vis.sciencemag.org/breakthrough20…
@sciencecohen The rapid development of efficacious #covid19 vaccines was clearly the science breakthrough of the year. But what about all the rest that went on in #covid19 science? My story is labeled “breakdown”, but the picture is complicated.
Read 18 tweets
17 Dec
Expected, but still good #covid19 vaccine news for Europe: @EMA_News has now moved up the likely date for Moderna vaccine as well. Meeting now scheduled for January 6 instead of January 12. Means vaccination with second vaccine likely to start a week earlier than thought in EU.
@EMA_News "Today, ahead of schedule, the company has submitted the last outstanding data package needed for the assessment of the application. This contains information that is specific to the manufacturing of the vaccine for the EU market“, says EMA press release.
@EMA_News "The number of infections is increasing across Europe and we are aware of the huge responsibility we have to get a vaccine to the market as quickly as is feasible, whilst maintaining the robustness of our scientific review”, EMA head Emer Cooke says in the press release.
Read 4 tweets
15 Dec
Big news for Europe: @EMA_News now planning to meet on 21 December not 29 to conclude assessment of Pfizer/Biontech #covid19 vaccine and hopefully recommend conditional marketing authorisation.
@EMA_News "Following receipt yesterday evening of additional data requested by the CHMP from the company and pending the outcome of its evaluation, an exceptional meeting of the CHMP has now been scheduled for 21 December to conclude if possible”, says press statement they just e-mailed.
@EMA_News That means the timeline for vaccinations across Europe is likely moving up by about a week.
Not surprised to see this given growing chorus of voices in recent days asking why Europe is taking longer than UK/US.
Read 4 tweets
10 Dec
#covid19 vaccines "will not be the magic bullet immediately”, says Emer Cooke, head of EMA. “For some time we will need to continue with social distancing and masks. There is no doubt about that.” But over time “we do hope that there will be a move to a more normal existence."
Cooke was answering questions from @EP_Environment. Says @EMA_News has "a very robust data set on which to make a decision, both on safety and efficacy” for the two mRNA vaccines. “The efficacy and safety looks very promising we have not seen adverse events coming up."
@EP_Environment @EMA_News "The information on the quality and manufacturing has come a little bit later”, says Cooke. "And that's also very complex, particularly because as has been pointed out, these are new types of vaccines, they require specialized expertise for us to examine that."
Read 5 tweets

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