Science asked me to -briefly- reflect on what happened in 2020. So, a thread on this year in science, the breakthroughs and breakdowns and where my head is at at the end of this difficult year.

Story is here:
vis.sciencemag.org/breakthrough20…
First, read @sciencecohen's beautiful, personal story on the vaccines:

“I can stop worrying about my mom dying alone in an intensive care unit, away from all who love her. And she can stop asking whether I’ll let her play mahjong with the girls”

vis.sciencemag.org/breakthrough20…
@sciencecohen The rapid development of efficacious #covid19 vaccines was clearly the science breakthrough of the year. But what about all the rest that went on in #covid19 science? My story is labeled “breakdown”, but the picture is complicated.
@sciencecohen Little of what scientists did to respond to #COVID19 was really new. As @florian_krammer told me “We took out all our fancy tools and applied them to this virus”.
What was new was not WHAT scientists did, but HOW they did it: Research was faster, more collaborative, more open.
@sciencecohen @florian_krammer The early diagnostic test from @c_drosten's lab, the @WHO mission report from China showing the virus could indeed be beaten, the collaboration behind the UK’s Recovery trial and the WHO’s Solidarity trial, the preprints being analysed in real time on twitter, ...
@sciencecohen @florian_krammer @c_drosten @WHO For me as a science journalist and for many interested people it was an incredible thing to see:
“The process of science was rarely as visible as this year. It was like watching open-heart surgery live on TV: messy but vital and riveting.”
@sciencecohen @florian_krammer @c_drosten @WHO But it wasn’t all rainbows and RNA. For all the evidence that was generated, the world often didn’t act on it. As @BillHanage told me: “It’s a little like watching a zombie movie in which half of the people can’t see the zombies and keep demanding to know what the fuss is about.”
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Some scientists contributed to this. The Great Barrington Declaration, questionable research hyping hydroxychloroquine or suggesting #sarscov2 was less deadly than thought: They all played into the public’s desire for easy solutions, for carrying on as before.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Some "may have been driven by a healthy distrust of accepted wisdom or a contrarian spirit, but the effect was reminiscent of industry’s playbook in the fights over tobacco and climate change: Create just enough confusion about the evidence to allow people to carry on as before."
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Others stood up for sound science and became targets. In Germany, for instance, @c_drosten has gone above and beyond in explaining research in this pandemic. He has rightly won praise, but also received death threats and police protection.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Many others spoke out as well and paid a price. Some of the worst vitriol was, once again, aimed at female scientists, who dared to give voice to their expertise.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Others decided to remain quiet, to concentrate on lab work and let others do the talking. For a while, @c_drosten seemed almost alone in Germany. But what is a scientist’s role in this crisis if not to explain. That, too, is something we need to talk about it when this is over.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage And all of this played out in a context that no scientist can afford to ignore anymore: an information ecosystem that helps misinformation and lies spread faster than scientific evidence, weakening our ability to respond to new threats.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage So yes, science worked faster than ever before and we have a vaccine after less than a year of this pandemic.
But more than 1,6 million people have died of #covid19.
It didn’t have to be this way.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Don’t get me wrong: We didn’t know everything and it was never going to be easy to deal with a virus with the specific characteristics of #SARSCoV2. But we knew enough to do more, to act better.
@sciencecohen @florian_krammer @c_drosten @WHO @BillHanage Where does all this leave us? @JeremyFarrar is optimistic. “I think we will look back after the horror of this and say, humanity is incredibly vulnerable,” he told me. “This will inspire a whole generation to come into science.”
I hope he is right. I hope we come out of this with a new appreciation for evidence and truth, with an understanding that we need to transform the information ecosystem we inhabit to be able to live in a shared reality.
But I’m stuck thinking: where would we be without vaccines? Where would we be in a crisis in which we really only have behaviour change to get out of it.
We have a vaccine now against #Sarscov2.
But there won’t be a vaccine against CO2.

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More from @kakape

19 Dec
“We urge governments throughout Europe to agree on clearly formulated common goals, coordinate their efforts, develop regionally adapted strategies to reach the goals, and thereby work resolutely towards low case numbers”, @CiesekSandra, @ViolaPriesemann and others in @TheLancet
The lack of a European strategy is something scientists and public health experts have pointed out again and again and it’s good to see it clearly formulated by a group of prominent researchers thelancet.com/journals/lance…
The authors also give a good, succinct summary of arguments for going for low #covid19 case numbers:
1. saving lives
2. saving the economy
3. control is more effective
4. makes TTI feasible
5. natural acquired herd immunity is not an option
6. no need for rapid policy changes
Read 4 tweets
19 Dec
Meine Kollegen vom @pandemiapodcast und ich haben viele Fragen bekommen in den vergangenen Wochen zu den neuen Impstoffen, zu ihrer schnellen Entwicklung, ihrer Sicherheit, zu Impfbereitschaft und Impfpflicht. Wir wollten das natürlich aufnehmen.
@pandemiapodcast Die neue Folge ist darum ein etwas wilder Ritt querfeldein und wir binden zusammen, worüber wir in den ersten Folgen der zweiten Staffel gesprochen haben: Impfstoffe, Pocken, Masern und eben #SARSCoV2. Die Folge gibt es hier: viertausendhertz.de/pan16/
Als Nächstes dann Gelbfieber!
@pandemiapodcast Vielen lieben Dank an @florian_krammer, @CorneliaBetsch, @Karl_Lauterbach, @NatalieGrams und Sidney Chalhoub, die sich alle viel Zeit genommen haben, um mit uns für die Folge zu sprechen.
Read 4 tweets
18 Dec
Global vaccine news: COVAX says deals are in place to access nearly 2 billion doses of #covid19 vaccine. "For the vast majority of these deals, COVAX has guaranteed access to a portion of the first wave of production, followed by volume scales as further supply becomes available”
The new deals include:
- an advance purchase agreement with AstraZeneca for 170 million doses of the AstraZeneca/Oxford candidate
- a memorandum of understanding (MoU) with Johnson & Johnson for 500 million doses of the Janssen candidate (investigated as single dose vaccine)
That’s on top of:
- agreement with Serum Institute of India for 200 million doses (plus option for 900 million more doses) of either AZ or Novavax vaccine
- statement of intent for 200 million doses of Sanofi/GSK vaccine candidate
Read 12 tweets
17 Dec
Expected, but still good #covid19 vaccine news for Europe: @EMA_News has now moved up the likely date for Moderna vaccine as well. Meeting now scheduled for January 6 instead of January 12. Means vaccination with second vaccine likely to start a week earlier than thought in EU.
@EMA_News "Today, ahead of schedule, the company has submitted the last outstanding data package needed for the assessment of the application. This contains information that is specific to the manufacturing of the vaccine for the EU market“, says EMA press release.
@EMA_News "The number of infections is increasing across Europe and we are aware of the huge responsibility we have to get a vaccine to the market as quickly as is feasible, whilst maintaining the robustness of our scientific review”, EMA head Emer Cooke says in the press release.
Read 4 tweets
15 Dec
Big news for Europe: @EMA_News now planning to meet on 21 December not 29 to conclude assessment of Pfizer/Biontech #covid19 vaccine and hopefully recommend conditional marketing authorisation.
@EMA_News "Following receipt yesterday evening of additional data requested by the CHMP from the company and pending the outcome of its evaluation, an exceptional meeting of the CHMP has now been scheduled for 21 December to conclude if possible”, says press statement they just e-mailed.
@EMA_News That means the timeline for vaccinations across Europe is likely moving up by about a week.
Not surprised to see this given growing chorus of voices in recent days asking why Europe is taking longer than UK/US.
Read 4 tweets
10 Dec
#covid19 vaccines "will not be the magic bullet immediately”, says Emer Cooke, head of EMA. “For some time we will need to continue with social distancing and masks. There is no doubt about that.” But over time “we do hope that there will be a move to a more normal existence."
Cooke was answering questions from @EP_Environment. Says @EMA_News has "a very robust data set on which to make a decision, both on safety and efficacy” for the two mRNA vaccines. “The efficacy and safety looks very promising we have not seen adverse events coming up."
@EP_Environment @EMA_News "The information on the quality and manufacturing has come a little bit later”, says Cooke. "And that's also very complex, particularly because as has been pointed out, these are new types of vaccines, they require specialized expertise for us to examine that."
Read 5 tweets

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