@Billy__Grove @KernNoris @KrutikaKuppalli @itosettiMD_MBA @Moderna Mutations are completely random, there's no rhyme or reason behind them. Only the ones that are similar/better than original will survive, rest will be completed out (Darwin's survival of fittest). (1/)
@Billy__Grove @KernNoris @KrutikaKuppalli @itosettiMD_MBA @Moderna But what can happen over time as a virus gets more virulent, which is to it's advantage one would think, is that at one point, it'll become so virulent, ie disease causing, that the host would become sicker sooner so transmission to next individual becomes lesser likely (2/)
@Billy__Grove @KernNoris @KrutikaKuppalli @itosettiMD_MBA @Moderna And because viruses need hosts (us) to make copies, there's a cliff of fitness after which it is to the virus' disadvantage to keep getting "better" at causing disease. This is when the virus will naturally fade away. (3/)
@Billy__Grove @KernNoris @KrutikaKuppalli @itosettiMD_MBA @Moderna In this case, SARS-Cov2 has struck a fine balance and is able to transmit (to some extent through the initial period of asymptomaticity even if eventually severe) plus cause disease in a small but significant % of infected hosts. So in a way, beauty of evolution at work (4/4)
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